Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys

Sen P, Naveen R, Houshmand N, Kia SM, Joshi M, Saha S, Jagtap K, Agarwal V, Nune A, Nikiphorou E, Tan AL, Shinjo SK, Ziade N, Velikova T, Milchert M, Parodis I, Gracia-Ramos AE, Cavagna L, Kuwana M, Knitza J, Makol A, Patel A, Pauling JD, Wincup C, Barman B, Tehozol EAZ, Serrano JR, De La Torre I, Colunga-Pedraza IJ, Merayo-Chalico J, Chibuzo OC, Katchamart W, Akawatcharangura Goo P, Shumnalieva R, Chen YM, Hoff LS, El Kibbi L, Halabi H, Vaidya B, Shaharir SS, Hasan ATMT, Dey D, Gutierrez CET, Caballero-Uribe CV, Lilleker JB, Salim B, Gheita T, Chatterjee T, Distler O, Saavedra MA, Day J, Chinoy H, Covad Study Grp SA, Kardes S, Kardes SA, Andreoli L, Lini D, Screiber K, Vince MN, Singh YP, Ranjan R, Jain A, Pandya SC, Pilania RK, Sharma A, Manoj MM, Gupta V, Kavadichanda CG, Patro PS, Ajmani S, Phatak S, Goswami RP, Chowdhury AC, Mathew AJ, Shenoy P, Asranna A, Bommakanti KT, Shukla A, Pande AR, Chandwar K, Ghodke A, Boro H, Fazal ZZ, Cansu DU, Yildirim R, Gasparyan AY, Del Papa N, Sambataro G, Fabiola A, Govoni M, Parisi S, Bocci EB, Sebastiani GD, Fusaro E, Sebastiani M, Quartuccio L, Franceschini F, Sainaghi PP, Orsolini G, De Angelis R, Danielli MG, Venerito V, Grignaschi S, Giollo A, Alluno A, Ioannone F, Fornaro M, Traboco LS, Wibowo SAK, Loarce-Martos J, Prieto-Gonzalez S, Gonzalez RA, Yoshida A, Nakashima R, Sato S, Kimura N, Kaneko Y, Gono T, Tomaras S, Proft FN, Holzer MT, Gromova MA, Aharonov O, Griger Z, Hmamouchi I, El Bouchti I, Baba Z, Giannini M, Maurier F, Campagne J, Meyer A, Langguth D, Limaye V, Needham M, Srivastav N, Hudson M, Landon-Cardinal O, Zuleta WGR, Arbelaez A, Cajas J, Silva JAP, Fonseca JE, Zimba O, Bohdana D, Ima-Edomwonyi U, Dedeke I, Airenakho E, Madu NH, Yerima A, Olaosebikan H, Becky A, Koussougbo OD, Palalane E, So H, Ugarte-Gil MF, Chinchay L, Bernaola JP, Pimentel V, Fathi HM, Mohammed RHA, Harifi G, Fuentes-Silva Y, Cabriza K, Losanto J, Colaman N, Cachafeiro-Vilar A, Bautista GG, Ho EJG, Gonzalez R, Nunez LS, Cristian Vergara M, Baez JT, Alonzo H, Pastelin CBS, Salinas RG, Obiols AQ, Chavez N, Ordonez AB, Argueta S, Llerena GAR, Sierra-Zorita R, Arrieta D, Hidalgo ER, Saenz R, Escalante MI, Morales R, Calapaqui W, Quezada I, Arredondo G, Agarwal V, Aggarwal R, Gupta L (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1093/rheumatology/kead057

Abstract

Objective COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys. Methods The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups. Results We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)]. Conclusion Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.

Authors with CRIS profile

Involved external institutions

Karolinska Institute Sweden (SE) Hl. Kliment Ochridski-Universität Sofia Bulgaria (BG) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Instituto Mexicano del Seguro Social Mexico (MX) Università degli Studi di Pavia Italy (IT) Nippon Medical School Japan (JP) Mayo Clinic United States (USA) (US) University of Virginia (UVA) United States (USA) (US) University of Bristol United Kingdom (GB) University College London (UCL) United Kingdom (GB) All India Institute of Medical Sciences, Guwahati (AIIMS Guwahati) India (IN) Instituto Nacional de Enfermedades Respiratorias Mexico (MX) Hospital General de Occidente (HGO) Mexico (MX) Mahidol University / มหาวิทยาลัยมหิดล Thailand (TH) Queen Savang Vadhana Memorial Hospital / โรงพยาบาลสมเด็จพระบรมราชเทวี ณ ศรีราชา Thailand (TH) Medical University Sofia / Медицински университет Bulgaria (BG) Taichung Veterans General Hospital Taiwan (TW) Universidade Potiguar (UnP) Brazil (BR) King Faisal Specialist Hospital & Research Centre Saudi Arabia (SA) National Center for Rheumatic Diseases (NCRD) Nepal (NP) The National University of Malaysia / Universiti Kebangsaan Malaysia (UKM) Malaysia (MY) Enam Medical College & Hospital (EMCH) / এনাম মেডিকেল কলেজ ও হাসপাতাল Bangladesh (BD) University of Ghana Ghana (GH) Pontifical Xavierian University / Pontificia Universidad Javeriana Colombia (CO) Universidad del Norte Colombia (CO) Manchester Academic Health Science Centre United Kingdom (GB) University of Illinois College of Medicine United States (USA) (US) University of Zurich / Universität Zürich (UZH) Switzerland (CH) Royal Melbourne Hospital (RMH) Australia (AU) University of Manchester United Kingdom (GB) Maulana Azad Medical College (MAMC) India (IN) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) University of Nevada Las Vegas United States (USA) (US) University of Pittsburgh United States (USA) (US) Byramjee Jeejeebhoy Government Medical College & Sassoon General Hospital India (IN) Mymensingh Medical College / ময়মনসিংহ মেডিকেল কলেজ Bangladesh (BD) King Edward Memorial Hospital and Seth G.S. Medical College / கிங் எட்வர்ட் நினைவு மருத்துவமனை,राजा एड्वर्ड स्मारक रुग्णालय व सेठ गोवर्धनदास सुंदरदास वैद्यकीय महाविद्यालय India (IN) Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS) India (IN) Southport and Ormskirk Hospital NHS Trust United Kingdom (GB) King’s College London United Kingdom (GB) Leeds Teaching Hospitals NHS Trust United Kingdom (GB) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB) Hospital Universitario Dr José Eleuterio Gonzalez Mexico (MX) Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico (MX) University of Nigeria Teaching Hospital (UNTH) Nigeria (NG) Fauji Foundation Hospital Pakistan (PK) Cairo University Egypt (EG) The Royal Wolverhampton NHS Trust / Royal Wolverhampton Hospitals NHS Trust United Kingdom (GB)

How to cite

APA:

Sen, P., Naveen, R., Houshmand, N., Kia, S.M., Joshi, M., Saha, S.,... Gupta, L. (2023). Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys. Rheumatology. https://dx.doi.org/10.1093/rheumatology/kead057

MLA:

Sen, Parikshit, et al. "Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys." Rheumatology (2023).

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