European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma
Sorbye H, Grande E, Pavel ME, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E (2023)
Publication Type: Journal article
Publication year: 2023
Journal
DOI: 10.1111/jne.13249
Abstract
This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and study results. These recommendations aim to pave the road for more standardized care for our patients resulting in improved outcomes. Prognosis is generally poor for digestive NEC, most are advanced at diagnosis and median survival in metastatic disease is 11-12 months. Surgery can be of benefit for localized disease after extensive preoperative imaging. Carboplatin in combination with etoposide is recommended as first-line treatment for metastatic disease. Irinotecan with fluoropyrimidines has the best evidence as second-line treatment. Immunotherapy plays a minor role in biomarker-unselected patients. Molecular profiling if available is encouraged to identify new targets. More prospective clinical trials are highly needed to fulfil the unmet needs in this field, especially on new predictive and prognostic biomarkers and to improve survival of patients with advanced disease.
Authors with CRIS profile
Involved external institutions
Haukeland University Hospital / Haukeland universitetssykehus
Norway (NO)
MD Anderson Cancer Center Madrid
Spain (ES)
Netherlands Cancer Institute (NKI)
Netherlands (NL)
European Institute of Oncology / Istituto Europeo di Oncologia (IEO)
Italy (IT)
Beatson West of Scotland Cancer Centre (BWSCC)
United Kingdom (GB)
Copenhagen University Hospital
Denmark (DK)
Universitätsspital Basel
Switzerland (CH)
University of Bologna / Università di Bologna
Italy (IT)
Université de Paris
France (FR)
Uppsala University
Sweden (SE)
Norway (NO)
MD Anderson Cancer Center Madrid
Spain (ES)
Netherlands Cancer Institute (NKI)
Netherlands (NL)
European Institute of Oncology / Istituto Europeo di Oncologia (IEO)
Italy (IT)
Beatson West of Scotland Cancer Centre (BWSCC)
United Kingdom (GB)
Copenhagen University Hospital
Denmark (DK)
Universitätsspital Basel
Switzerland (CH)
University of Bologna / Università di Bologna
Italy (IT)
Université de Paris
France (FR)
Uppsala University
Sweden (SE)
How to cite
APA:
Sorbye, H., Grande, E., Pavel, M.E., Tesselaar, M., Fazio, N., Reed, N.S.,... Tiensuu Janson, E. (2023). European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma. Journal of Neuroendocrinology. https://doi.org/10.1111/jne.13249
MLA:
Sorbye, Halfdan, et al. "European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma." Journal of Neuroendocrinology (2023).
BibTeX: Download