Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases

Britzen-Laurent N, Weidinger C, Stürzl M (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 24

Journal Issue: 6

DOI: 10.3390/ijms24065517

Abstract

Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders with a complex etiology, which represent a clinical challenge due to their often therapy-refractory nature. In IBD, inflammation of the intestinal mucosa is characterized by strong and sustained leukocyte infiltration, resulting in the loss of epithelial barrier function and subsequent tissue destruction. This is accompanied by the activation and the massive remodeling of mucosal micro-vessels. The role of the gut vasculature in the induction and perpetuation of mucosal inflammation is receiving increasing recognition. While the vascular barrier is considered to offer protection against bacterial translocation and sepsis after the breakdown of the epithelial barrier, endothelium activation and angiogenesis are thought to promote inflammation. The present review examines the respective pathological contributions of the different phenotypical changes observed in the microvascular endothelium during IBD, and provides an overview of potential vessel-specific targeted therapy options for the treatment of IBD.

Authors with CRIS profile

Nathalie Britzen-Laurent Professur für Molekulare und Experimentelle Chirurgie Michael Stürzl Professur für Molekulare und Experimentelle Chirurgie

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Britzen-Laurent, N., Weidinger, C., & Stürzl, M. (2023). Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases. International Journal of Molecular Sciences, 24(6). https://doi.org/10.3390/ijms24065517

MLA:

Britzen-Laurent, Nathalie, Carl Weidinger, and Michael Stürzl. "Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases." International Journal of Molecular Sciences 24.6 (2023).

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