Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study

Shinjo SK, Kim M, Hoff LS, Missé RG, Sen P, Naveen R, Day J, Cordeiro RA, Júnior JG, Chatterjee T, Lilleker JB, Agarwal V, Kardes S, Milchert M, Gheita T, Salim B, Velikova T, Gracia-Ramos AE, Parodis I, O'Callaghan AS, Nikiphorou E, Makol A, Tan AL, Cavagna L, Saavedra MA, Ziade N, Knitza J, Kuwana M, Nune A, Distler O, Chinoy H, Agarwal V, Aggarwal R, Gupta L (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1111/1756-185X.14636

Abstract

Objectives: To compare pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs). Methods: Data were collected from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an international cross-sectional online survey, from December 2020 to August 2021. Pain experienced in the preceding week was assessed using numeral rating scale (NRS). We performed a negative binomial regression analysis to assess pain in IIMs subtypes and whether demographics, disease activity, general health status, and physical function had an impact on pain scores. Results: Of 6988 participants included, 15.1% had IIMs, 27.9% had other AIRDs, and 57.0% were wAIDs. The median pain NRS in patients with IIMs, other AIRDs, and wAIDs were 2.0 (interquartile range [IQR] = 1.0–5.0), 3.0 (IQR = 1.0–6.0), and 1.0 (IQR = 0–2.0), respectively (P < 0.001). Regression analysis adjusted for gender, age, and ethnicity revealed that overlap myositis and antisynthetase syndrome had the highest pain (NRS = 4.0, 95% CI = 3.5–4.5, and NRS = 3.6, 95% CI = 3.1–4.1, respectively). An additional association between pain and poor functional status was observed in all groups. Female gender was associated with higher pain scores in almost all scenarios. Increasing age was associated with higher pain NRS scores in some scenarios of disease activity, and Asian and Hispanic ethnicities had reduced pain scores in some functional status scenarios. Conclusion: Patients with IIMs reported higher pain levels than wAIDs, but less than patients with other AIRDs. Pain is a disabling manifestation of IIMs and is associated with a poor functional status.

Authors with CRIS profile

Involved external institutions

University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) University of Illinois at Chicago United States (USA) (US) Universidade Potiguar (UnP) Brazil (BR) Maulana Azad Medical College (MAMC) India (IN) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) Royal Melbourne Hospital (RMH) Australia (AU) University of Manchester United Kingdom (GB) Mahatma Gandhi Mission Medical College and Hospital India (IN) Istanbul University / İstanbul Üniversitesi Turkey (TR) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Fauji Foundation Hospital Pakistan (PK) Aleksandrovska University Hospital / университетска болница "Александровска" Bulgaria (BG) Instituto Mexicano del Seguro Social Mexico (MX) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona Spain (ES) King’s College London United Kingdom (GB) Mayo Clinic United States (USA) (US) NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU) United Kingdom (GB) Università degli Studi di Pavia Italy (IT) Southport and Ormskirk Hospital NHS Trust United Kingdom (GB) Universitätsspital Zürich (USZ) Switzerland (CH) University of Pittsburgh United States (USA) (US) Centro Medico Nacional Siglo XXI Mexico (MX) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB)

How to cite

APA:

Shinjo, S.K., Kim, M., Hoff, L.S., Missé, R.G., Sen, P., Naveen, R.,... Gupta, L. (2023). Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study. International Journal of Rheumatic Diseases. https://doi.org/10.1111/1756-185X.14636

MLA:

Shinjo, Samuel Katsuyuki, et al. "Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study." International Journal of Rheumatic Diseases (2023).

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