Genotoxicity of oxidative hair dye precursors: A systematic review
Babić Ž, Hallmann S, Havmose MS, Johansen JD, John SM, Symanzik C, Uter W, Weinert P, van der Molen HF, Kezic S, Macan J, Turk R (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 42
Pages Range: 9603271231159803
DOI: 10.1177/09603271231159803
Abstract
This systematic review, conducted according to the PRISMA guidelines, focuses on genotoxicity of oxidative hair dye precursors. The search for original papers published from 2000 to 2021 was performed in Medline, Web of Science, Cochrane registry, Scientific Committee on Consumer Safety of the European Commission and German MAK Commission opinions. Nine publications on genotoxicity of p-phenylenediamine (PPD) and toluene-2,5-diamine (p-toluylenediamine; PTD) were included, reporting results of 17 assays covering main genotoxicity endpoints. PPD and PTD were positive in bacterial mutation invitro assay, and PPD tested positive also for somatic cell mutations in the Rodent Pig-a assay invivo. Clastogenicity of PPD and PTD was revealed by invitro chromosomal aberration assay. The alkaline comet assay invitro showed DNA damage after PPD exposure, which was not confirmed invivo, where PTD exhibited positive results. PPD induced micronucleus formation invitro, and increased micronucleus frequencies in mice erythrocytes following high dose oral exposure invivo. Based on the results of a limited number of data from the classical genotoxicity assay battery, this systematic review indicates genotoxic potential of hair dye precursors PPD and PTD, which may present an important health concern for consumers and in particular for professional hairdressers.
Authors with CRIS profile
Involved external institutions
University of Copenhagen
Denmark (DK)
Universität Osnabrück
Germany (DE)
University of Amsterdam
Netherlands (NL)
Institute for Medical Research and Occupational Health
Croatia (HR)
Denmark (DK)
Universität Osnabrück
Germany (DE)
University of Amsterdam
Netherlands (NL)
Institute for Medical Research and Occupational Health
Croatia (HR)
How to cite
APA:
Babić, Ž., Hallmann, S., Havmose, M.S., Johansen, J.D., John, S.M., Symanzik, C.,... Turk, R. (2023). Genotoxicity of oxidative hair dye precursors: A systematic review. Human & Experimental Toxicology, 42, 9603271231159803. https://doi.org/10.1177/09603271231159803
MLA:
Babić, Željka, et al. "Genotoxicity of oxidative hair dye precursors: A systematic review." Human & Experimental Toxicology 42 (2023): 9603271231159803.
BibTeX: Download