CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming
Brewitz A, Eickhoff S, Daehling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmueller W (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 46
Pages Range: 205-219
Journal Issue: 2
DOI: 10.1016/j.immuni.2017.01.003
Abstract
Adaptive cellular immunity is initiated by antigen-specific interactions between T lymphocytes and dendritic cells (DCs). Plasmacytoid DCs (pDCs) support antiviral immunity by linking innate and adaptive immune responses. Here we examined pDC spatiotemporal dynamics during viral infection to uncover when, where, and how they exert their functions. We found that pDCs accumulated at sites of CD8+ T cell antigen-driven activation in a CCR5-dependent fashion. Furthermore, activated CD8+ T cells orchestrated the local recruitment of lymph node-resident XCR1 chemokine receptor-expressing DCs via secretion of the XCL1 chemokine. Functionally, this CD8+ T cell-mediated reorganization of the local DC network allowed for the interaction and cooperation of pDCs and XCR1+ DCs, thereby optimizing XCR1+ DC maturation and cross-presentation. These data support a model in which CD8+ T cells upon activation create their own optimal priming microenvironment by recruiting additional DC subsets to the site of initial antigen recognition.
Involved external institutions
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
The University of Melbourne
Australia (AU)
Robert Koch-Institut (RKI)
Germany (DE)
Università Vita-Salute San Raffaele (UniSR)
Italy (IT)
Charité - Universitätsmedizin Berlin
Germany (DE)
Wakayama Medical University
Japan (JP)
Washington University in St. Louis
United States (USA) (US)
National Institute of Allergy and Infectious Diseases
United States (USA) (US)
Germany (DE)
The University of Melbourne
Australia (AU)
Robert Koch-Institut (RKI)
Germany (DE)
Università Vita-Salute San Raffaele (UniSR)
Italy (IT)
Charité - Universitätsmedizin Berlin
Germany (DE)
Wakayama Medical University
Japan (JP)
Washington University in St. Louis
United States (USA) (US)
National Institute of Allergy and Infectious Diseases
United States (USA) (US)
How to cite
APA:
Brewitz, A., Eickhoff, S., Daehling, S., Quast, T., Bedoui, S., Kroczek, R.A.,... Kastenmueller, W. (2017). CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity, 46(2), 205-219. https://doi.org/10.1016/j.immuni.2017.01.003
MLA:
Brewitz, Anna, et al. "CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming." Immunity 46.2 (2017): 205-219.
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