Recovering a chemotopic feature space from a group of fruit fly antenna chemosensors
Strauch M, Mukunda L, Luedke A, Galizia CG, Merhof D (2018)
Publication Type: Conference contribution
Publication year: 2018
Publisher: Institute of Electrical and Electronics Engineers Inc.
Pages Range: 163-169
Conference Proceedings Title: Proceedings - 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering, BIBE 2018
Event location: Taichung, TWN
ISBN: 9781538662168
Abstract
The ensemble of odorant receptors on the antenna of the fruit fly Drosophila melanogaster acts as an encoder for chemical molecules. Chemically similar odorants elicit activity in similar subsets of the receptors, spanning a so-called chemotopic feature space that enables chemical similarity search. A compound signal of receptor activity can be read out by calcium imaging of the antenna, yet without revealing corresponding receptors on different antennae. Employing Canonical Correlation Analysis (CCA) for multiple sets, we show that a consensus feature space can nevertheless be recovered from a group of variable antenna sensors that all respond to a common sequence of odorants. In the chemotopic consensus feature space, properties of novel odorants can be inferred, demonstrating how fruit fly antenna chemosensors may be employed as an alternative to electronic noses.
Involved external institutions
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Germany (DE)
Universität Konstanz
Germany (DE)
Germany (DE)
Universität Konstanz
Germany (DE)
How to cite
APA:
Strauch, M., Mukunda, L., Luedke, A., Galizia, C.G., & Merhof, D. (2018). Recovering a chemotopic feature space from a group of fruit fly antenna chemosensors. In Proceedings - 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering, BIBE 2018 (pp. 163-169). Taichung, TWN: Institute of Electrical and Electronics Engineers Inc..
MLA:
Strauch, Martin, et al. "Recovering a chemotopic feature space from a group of fruit fly antenna chemosensors." Proceedings of the 18th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2018, Taichung, TWN Institute of Electrical and Electronics Engineers Inc., 2018. 163-169.
BibTeX: Download