The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT
Einsele H, Rasche L, Topp MS, Kortuem KM, Duell J (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 54
Pages Range: 721-726
DOI: 10.1038/s41409-019-0596-z
Abstract
One of the remaining and unresolved problems in allogeneic stem cell transplantation, especially following a T cell-depleted transplant as often performed in the setting of haploidentical transplantation, is the relapse of the underlying hematological malignancy. It has been demonstrated that in the last years we have made major progress in controlling infections, acute and chronic GvHD and making stem cell transplantation available to elderly patients. However, little improvement has been made to achieve better tumor control and to lower the relapse rate. Thus, novel immunotherapeutic strategies are increasingly used prior to or even following allogeneic stem cell transplantation to better control the underlying malignancy and thus, to reduce the relapse rate. These novel immunotherapeutic strategies comprise monoclonal antibodies, immunotoxins and even more effective T cell redirecting strategies like bispecific antibodies and T cells transduced with either chimeric antigen receptors (CAR) or (affinity-tuned) T cell receptors (TCR).
Involved external institutions
Germany (DE)How to cite
APA:
Einsele, H., Rasche, L., Topp, M.S., Kortuem, K.M., & Duell, J. (2019). The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT. Bone Marrow Transplantation, 54, 721-726. https://doi.org/10.1038/s41409-019-0596-z
MLA:
Einsele, Hermann, et al. "The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT." Bone Marrow Transplantation 54 (2019): 721-726.
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