Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche
Mondor I, Baratin M, Lagueyrie M, Saro L, Henri S, Gentek R, Suerinck D, Kastenmuller W, Jiang JX, Bajenoff M (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 50
Pages Range: 1453-1466.e4
Journal Issue: 6
DOI: 10.1016/j.immuni.2019.04.002
Abstract
In lymph nodes, subcapsular sinus macrophages (SSMs) form an immunological barrier that monitors lymph drained from peripheral tissues. Upon infection, SSMs activate B and natural killer T (NKT) cells while secreting inflammatory mediators. Here, we investigated the mechanisms regulating development and homeostasis of SSMs. Embryonic SSMs originated from yolk sac hematopoiesis and were replaced by a postnatal wave of bone marrow (BM)-derived monocytes that proliferated to establish the adult SSM network. The SSM network self-maintained by proliferation with minimal BM contribution. Upon pathogen-induced transient deletion, BM-derived cells contributed to restoring the SSM network. Lymphatic endothelial cells (LECs) were the main source of CSF-1 within the lymph node and conditional deletion of Csf1 in adult LECs decreased the network of SSMs and medullary sinus macrophages (MSMs). Thus, SSMs have a dual hematopoietic origin, and LECs are essential to the niche supporting these macrophages. Mondor et al. demonstrate that subcapsular sinus macrophages (SSMs) self-maintain by proliferation in the adult mouse lymph node and that homeostasis of SSMs and medullary sinus macrophages (MSMs) relies on secretion of CSF-1 by neighboring lymphatic endothelial cells (LECs).
Involved external institutions
Aix-Marseille University / Aix-Marseille Université
France (FR)
Julius-Maximilians-Universität Würzburg
Germany (DE)
University of Texas Health Science Center at San Antonio (UTHSCSA)
United States (USA) (US)
France (FR)
Julius-Maximilians-Universität Würzburg
Germany (DE)
University of Texas Health Science Center at San Antonio (UTHSCSA)
United States (USA) (US)
How to cite
APA:
Mondor, I., Baratin, M., Lagueyrie, M., Saro, L., Henri, S., Gentek, R.,... Bajenoff, M. (2019). Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche. Immunity, 50(6), 1453-1466.e4. https://doi.org/10.1016/j.immuni.2019.04.002
MLA:
Mondor, Isabelle, et al. "Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche." Immunity 50.6 (2019): 1453-1466.e4.
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