New targets and technologies for CAR-T cells
Freitag F, Maucher M, Riester Z, Hudecek M (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 32
Pages Range: 510-517
Journal Issue: 5
DOI: 10.1097/CCO.0000000000000653
Abstract
Purpose of review Immunotherapy with gene-engineered chimeric antigen receptor (CAR)-T cells has curative potential in advanced malignancies and undergoes a surging preclinical and clinical development. Here, we present a selection of new targets and technologies that illustrate the progress that is being made with the aspiration to make CAR-T cell therapy a universally applicable and effective treatment in cancer medicine. Recent findings There is a rich pipeline of new target antigens for CAR-T cells in hematology and oncology that are rated based on uniformity but also stability of expression on tumor cells under therapeutic pressure. New technologies in CAR-T cell engineering are directed at neutralizing inhibitory ligands and factors in the tumor microenvironment, preventing CAR-T cell exhaustion and enhancing selectivity for tumor cells with 'smart' CAR designs. The manufacture of CAR-T cells using virus-free protocols is anticipated to reduce supply-chain complexity and to improve patient access. Summary CD19 CAR-T cell therapy is an approved treatment for B-cell leukemia and -lymphoma and considering the current 'target and technology' pipeline, we anticipate that additional CAR-T cell products will accomplish their 'breakthrough' and clinical proof-of-concept in other indications in hematology and in oncology. Technologies to enhance therapeutic index and facilitate manufacturing will be key for assuring availability and accessibility of CAR-T cell products and their implementation into routine clinical practice.
Involved external institutions
Germany (DE)How to cite
APA:
Freitag, F., Maucher, M., Riester, Z., & Hudecek, M. (2020). New targets and technologies for CAR-T cells. Current Opinion in Oncology, 32(5), 510-517. https://doi.org/10.1097/CCO.0000000000000653
MLA:
Freitag, Fabian, et al. "New targets and technologies for CAR-T cells." Current Opinion in Oncology 32.5 (2020): 510-517.
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