Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells

De Giovanni M, Cutillo V, Giladi A, Sala E, Maganuco CG, Medaglia C, Di Lucia P, Bono E, Cristofani C, Consolo E, Giustini L, Fiore A, Eickhoff S, Kastenmueller W, Amit I, Kuka M, Iannacone M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Nature Immunology Nature Research

Book Volume: 21

Pages Range: 321-330

Journal Issue: 3

DOI: 10.1038/s41590-020-0596-6

Abstract

Differentiation of CD4+ T cells into either follicular helper T (TFH) or type 1 helper T (TH1) cells influences the balance between humoral and cellular adaptive immunity, but the mechanisms whereby pathogens elicit distinct effector cells are incompletely understood. Here we analyzed the spatiotemporal dynamics of CD4+ T cells during infection with recombinant vesicular stomatitis virus (VSV), which induces early, potent neutralizing antibodies, or recombinant lymphocytic choriomeningitis virus (LCMV), which induces a vigorous cellular response but inefficient neutralizing antibodies, expressing the same T cell epitope. Early exposure of dendritic cells to type I interferon (IFN), which occurred during infection with VSV, induced production of the cytokine IL-6 and drove TFH cell polarization, whereas late exposure to type I IFN, which occurred during infection with LCMV, did not induce IL-6 and allowed differentiation into TH1 cells. Thus, tight spatiotemporal regulation of type I IFN shapes antiviral CD4+ T cell differentiation and might instruct vaccine design strategies.

Involved external institutions

Università Vita-Salute San Raffaele (UniSR) IT Italy (IT) Weizmann Institute of Science IL Israel (IL) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

De Giovanni, M., Cutillo, V., Giladi, A., Sala, E., Maganuco, C.G., Medaglia, C.,... Iannacone, M. (2020). Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells. Nature Immunology, 21(3), 321-330. https://doi.org/10.1038/s41590-020-0596-6

MLA:

De Giovanni, Marco, et al. "Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells." Nature Immunology 21.3 (2020): 321-330.

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