Circulating interleukin-4 is associated with a systemic t cell response against tumor-associated antigens in treatment-naïve patients with resectable non-small-cell lung cancer

Safi S, Yamauchi Y, Hoffmann H, Weichert W, Jost PJ, Winter H, Muley T, Beckhove P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cancers MDPI

Book Volume: 12

Pages Range: 1-20

Article Number: 3496

Journal Issue: 12

DOI: 10.3390/cancers12123496

Abstract

Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these T cell responses remain unclear. We quantified the levels of 27 cytokines in the peripheral blood and tumor tissues from treatment-naïve patients with NSCLC (n = 36) and analyzed associations between local and systemic cytokine profiles and both TA-specific T cell responses and clinical parameters. We defined T cell responders as patients with circulating T cells that were reactive to TAs and T cell nonresponders as patients without detectable TA-specific T cells. TA-specific T cell responses were correlated with serum cytokine levels, particularly the levels of interleukin(IL)-4 and granulocyte colony-stimulating factor (G-CSF), but poorly correlated with the cytokine levels in tumor tissues. Nonresponders showed significantly higher serum IL-4 levels than responders (p = 0.03); the predicted probability of being a responder was higher for individuals with low serum IL-4 levels. In multivariable Cox regression analyses, in addition to IL-4 (hazard ratio (HR) 2.8 (95% confidence interval (CI): 0.78–9.9); p = 0.116), the age-adjusted IL-8 level (HR 3.9 (95% CI: 1.05–14.5); p = 0.042) predicted tumor recurrence. However, this study included data for many cytokines without adjustment for multiple testing; thus, the observed differences in IL-4 or IL-8 levels might be incidental findings. Therefore, additional studies are necessary to confirm these results.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Teikyo University JP Japan (JP) Universitätsklinikum Heidelberg DE Germany (DE) Deutsches Zentrum für Lungenforschung e.V. (DZL) DE Germany (DE) Universitätsklinikum Regensburg DE Germany (DE)

How to cite

APA:

Safi, S., Yamauchi, Y., Hoffmann, H., Weichert, W., Jost, P.J., Winter, H.,... Beckhove, P. (2020). Circulating interleukin-4 is associated with a systemic t cell response against tumor-associated antigens in treatment-naïve patients with resectable non-small-cell lung cancer. Cancers, 12(12), 1-20. https://doi.org/10.3390/cancers12123496

MLA:

Safi, Seyer, et al. "Circulating interleukin-4 is associated with a systemic t cell response against tumor-associated antigens in treatment-naïve patients with resectable non-small-cell lung cancer." Cancers 12.12 (2020): 1-20.

BibTeX: Download