Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Flommersfeld S, Bottcher JP, Ersching J, Flossdorf M, Meiser P, Pachmayr LO, Leube J, Hensel I, Jarosch S, Zhang Q, Chaudhry MZ, Andrae I, Schiemann M, Busch DH, Cicin-Sain L, Sun JC, Gasteiger G, Victora GD, Hoefer T, Buchholz VR, Grassmann S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Immunity Elsevier

Book Volume: 54

Pages Range: 2288-2304.e7

Journal Issue: 10

DOI: 10.1016/j.immuni.2021.08.002

Abstract

Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Rockefeller University US United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) Helmholtz-Zentrum für Infektionsforschung (HZI) DE Germany (DE) Memorial Sloan Kettering Cancer Center US United States (USA) (US) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Flommersfeld, S., Bottcher, J.P., Ersching, J., Flossdorf, M., Meiser, P., Pachmayr, L.O.,... Grassmann, S. (2021). Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. Immunity, 54(10), 2288-2304.e7. https://dx.doi.org/10.1016/j.immuni.2021.08.002

MLA:

Flommersfeld, Sophie, et al. "Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection." Immunity 54.10 (2021): 2288-2304.e7.

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