Identification of a miRNA based model to detect prognostic subgroups in patients with aggressive B-cell lymphoma
Nordmo C, Glehr G, Altenbuchinger M, Spang R, Ziepert M, Horn H, Staiger AM, Ott G, Schmitz N, Held G, Einsele H, Topp M, Rosenwald A, Rauert-Wunderlich H (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 62
Pages Range: 1107-1115
Journal Issue: 5
DOI: 10.1080/10428194.2020.1861268
Abstract
In order to differentiate prognostic subgroups of patients with aggressive B-cell lymphoma, we analyzed the expression of 800 miRNAs with the NanoString nCounter human miRNA assay on a cohort of 228 FFPE samples of patients enrolled in the RICOVER-60 and MegaCHOEP trials. We identified significant miRNA signatures for overall survival (OS) and progression-free survival (PFS) by LASSO-penalized linear Cox-regression. High expression levels of miR-130a-3p and miR-423-5p indicate a better prognosis, whereas high levels of miR-374b-5p, miR-590-5p, miR-186-5p, and miR-106b-5p increase patients’ risk levels for OS. Regarding PFS high expression of miR-365a-5p in addition to the other two miRNAs improves the prognosis and high levels of miR374a-5p, miR-106b-5p, and miR-590-5p, connects with increased risk and poor prognosis. We identified miRNA signatures to subdivide patients into two different risk groups. These prognostic models may be used in risk stratification in future clinical trials and help making personalized therapy decisions.
Involved external institutions
Universitätsklinikum Würzburg
Germany (DE)
Universität Regensburg
Germany (DE)
Universität Leipzig
Germany (DE)
Robert-Bosch-Krankenhaus
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Westpfalz-Klinikum
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Germany (DE)
Universität Regensburg
Germany (DE)
Universität Leipzig
Germany (DE)
Robert-Bosch-Krankenhaus
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Westpfalz-Klinikum
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
How to cite
APA:
Nordmo, C., Glehr, G., Altenbuchinger, M., Spang, R., Ziepert, M., Horn, H.,... Rauert-Wunderlich, H. (2021). Identification of a miRNA based model to detect prognostic subgroups in patients with aggressive B-cell lymphoma. Leukemia & Lymphoma, 62(5), 1107-1115. https://doi.org/10.1080/10428194.2020.1861268
MLA:
Nordmo, Carmen, et al. "Identification of a miRNA based model to detect prognostic subgroups in patients with aggressive B-cell lymphoma." Leukemia & Lymphoma 62.5 (2021): 1107-1115.
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