Immuno-metabolic interfaces in cardiac disease and failure
Bertero E, Dudek J, Cochain C, Delgobo M, Ramos G, Gerull B, Higuchi T, Vaeth M, Zernecke A, Frantz S, Hofmann U, Maack C (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
Book Volume: 118
Pages Range: 37-52
Journal Issue: 1
DOI: 10.1093/cvr/cvab036
Abstract
The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of a wide spectrum of cardiovascular diseases, including heart failure. Here, we provide an overview of the fundamental aspects of the interrelation between inflammation and metabolism, ranging from the role of metabolism in immune cell function to the processes how inflammation modulates systemic and cardiac metabolism. Furthermore, we discuss how disruption of this immuno-metabolic interface is involved in the development and progression of cardiovascular disease, with a special focus on heart failure. Finally, we present new technologies and therapeutic approaches that have recently emerged and hold promise for the future of cardiovascular medicine.
Involved external institutions
Germany (DE)How to cite
APA:
Bertero, E., Dudek, J., Cochain, C., Delgobo, M., Ramos, G., Gerull, B.,... Maack, C. (2022). Immuno-metabolic interfaces in cardiac disease and failure. Cardiovascular Research, 118(1), 37-52. https://dx.doi.org/10.1093/cvr/cvab036
MLA:
Bertero, Edoardo, et al. "Immuno-metabolic interfaces in cardiac disease and failure." Cardiovascular Research 118.1 (2022): 37-52.
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