Kabat AM, Hackl A, Sanin DE, Zeis P, Grzes KM, Baixauli F, Kyle R, Caputa G, Edwards-Hicks J, Villa M, Rana N, Curtis JD, Castoldi A, Cupovic J, Dreesen L, Sibilia M, Pospisilik JA, Urban JF, Gruen D, Pearce EL, Pearce EJ (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 7
Article Number: eadd3263
Journal Issue: 76
DOI: 10.1126/sciimmunol.add3263
Type 2 immunity is associated with adipose tissue (AT) homeostasis and infection with parasitic helminths, but whether AT participates in immunity to these parasites is unknown. We found that the fat content of mesenteric AT (mAT) declined in mice during infection with a gut-restricted helminth. This was associated with the accumulation of metabolically activated, interleukin-33 (IL-33), thymic stromal lymphopoietin (TSLP), and extracellular matrix (ECM)-producing stromal cells. These cells shared transcriptional features, including the expression of Dpp4 and Pi16, with multipotent progenitor cells (MPC) that have been identified in numerous tissues and are reported to be capable of differentiating into fibroblasts and adipocytes. Concomitantly, mAT became infiltrated with resident T helper 2 (T
APA:
Kabat, A.M., Hackl, A., Sanin, D.E., Zeis, P., Grzes, K.M., Baixauli, F.,... Pearce, E.J. (2022). Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection. Science immunology, 7(76). https://doi.org/10.1126/sciimmunol.add3263
MLA:
Kabat, Agnieszka M., et al. "Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection." Science immunology 7.76 (2022).
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