Embryonic and neonatal waves generate distinct populations of hepatic ILC1s

Sparano C, Solís-Sayago D, Vijaykumar A, Rickenbach C, Vermeer M, Ingelfinger F, Litscher G, Fonseca A, Mussak C, Mayoux M, Friedrich C, Nombela-Arrieta C, Gasteiger G, Becher B, Tugues S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Science immunology American Association for the Advancement of Science

Book Volume: 7

Article Number: eabo6641

Journal Issue: 75

DOI: 10.1126/sciimmunol.abo6641

Abstract

Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) cells and tissue-resident ILC1s are critical for host defense against pathogens and tumors. Despite a growing understanding of their role in homeostasis and disease, the ontogeny of group 1 ILCs remains largely unknown. Here, we used fate mapping and single-cell transcriptomics to comprehensively investigate the origin and turnover of murine group 1 ILCs. Whereas cNK cells are continuously replaced throughout life, we uncovered tissue-dependent development and turnover of ILC1s. A first wave of ILC1s emerges during embryogenesis in the liver and transiently colonizes fetal tissues. After birth, a second wave quickly replaces ILC1s in most tissues apart from the liver, where they layer with embryonic ILC1s, persist until adulthood, and undergo a specific developmental program. Whereas embryonically derived ILC1s give rise to a cytotoxic subset, the neonatal wave establishes the full spectrum of ILC1s. Our findings uncover key ontogenic features of murine group 1 ILCs and their association with cellular identities and functions.

Involved external institutions

University of Zurich / Universität Zürich (UZH) CH Switzerland (CH) Universitätsspital Zürich (USZ) CH Switzerland (CH) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Sparano, C., Solís-Sayago, D., Vijaykumar, A., Rickenbach, C., Vermeer, M., Ingelfinger, F.,... Tugues, S. (2022). Embryonic and neonatal waves generate distinct populations of hepatic ILC1s. Science immunology, 7(75). https://dx.doi.org/10.1126/sciimmunol.abo6641

MLA:

Sparano, Colin, et al. "Embryonic and neonatal waves generate distinct populations of hepatic ILC1s." Science immunology 7.75 (2022).

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