68Ga-Pentixafor PET/CT for Detection of Chemokine Receptor CXCR4 Expression in Myeloproliferative Neoplasms

Kraus S, Dierks A, Rasche L, Kertels O, Kircher M, Schirbel A, Zovko J, Steinbrunn T, Tibes R, Wester HJ, Buck AK, Einsele H, Kortum KM, Rosenwald A, Lapa C (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Journal of Nuclear Medicine Society of Nuclear Medicine

Book Volume: 63

Pages Range: 96-99

Journal Issue: 1

DOI: 10.2967/jnumed.121.262206

Abstract

C-X-C motif chemokine receptor 4 (CXCR4) is an attractive target for cancer diagnosis and treatment, as it is overexpressed in many solid and hematologic malignancies. This study investigated the feasibility of CXCR4-directed imaging with PET/CT using 68Ga-pentixafor to visualize and quantify disease involvement in myeloproliferative neoplasms (MPNs). Methods: Twelve patients with MPNs (4 with primary myelofibrosis, 6 with essential thrombocythemia, and 2 with polycythemia vera) and 5 controls underwent 68Ga-pentixafor PET/CT. Imaging findings were compared with immunohistochemical stainings, laboratory data, and splenic volume. Results: 68Ga-pentixafor PET/ CT was visually positive in 12 of 12 patients, and CXCR4 target specificity could be confirmed by immunohistochemical staining. A significantly higher tracer uptake could be detected in the bone marrow of MPN patients (SUVmean, 6.45±2.34 vs. 4.44±1.24). Dynamic changes in CXCR4 expression determined by 68Ga-pentixafor PET/ CT corresponded with treatment response. Conclusion: 68Ga-pentixafor PET/CT represents a novel diagnostic tool to noninvasively detect and quantify the extent of disease involvement inMPNs. COPYRIGHT

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Kraus, S., Dierks, A., Rasche, L., Kertels, O., Kircher, M., Schirbel, A.,... Lapa, C. (2022). 68Ga-Pentixafor PET/CT for Detection of Chemokine Receptor CXCR4 Expression in Myeloproliferative Neoplasms. Journal of Nuclear Medicine, 63(1), 96-99. https://doi.org/10.2967/jnumed.121.262206

MLA:

Kraus, Sabrina, et al. "68Ga-Pentixafor PET/CT for Detection of Chemokine Receptor CXCR4 Expression in Myeloproliferative Neoplasms." Journal of Nuclear Medicine 63.1 (2022): 96-99.

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