Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

Ataide MA, Knöpper K, Cruz de Casas P, Ugur M, Eickhoff S, Zou M, Shaikh H, Trivedi A, Grafen A, Yang T, Prinz I, Ohlsen K, Gomez de Agüero M, Beilhack A, Huehn J, Gaya M, Saliba AE, Gasteiger G, Kastenmüller W (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Immunity Elsevier

Book Volume: 55

Pages Range: 1813-1828.e9

Journal Issue: 10

DOI: 10.1016/j.immuni.2022.07.019

Abstract

Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs) continuously inform lymphocytes on changes in drained tissues. Here, using LN transplantation, single-cell RNA-seq, spectral flow cytometry, and a transgenic mouse model for photolabeling, we showed that tissue-derived unconventional T cells (UTCs) migrate via the lymphatic route to locally draining LNs. As each tissue harbored a distinct spectrum of UTCs with locally adapted differentiation states and distinct T cell receptor repertoires, every draining LN was thus populated by a distinctive tissue-determined mix of these lymphocytes. By making use of single UTC lineage-deficient mouse models, we found that UTCs functionally cooperated in interconnected units and generated and shaped characteristic innate and adaptive immune responses that differed between LNs that drained distinct tissues. Lymphatic migration of UTCs is, therefore, a key determinant of site-specific immunity initiated in distinct LNs with potential implications for vaccination strategies and immunotherapeutic approaches.

Involved external institutions

Julius-Maximilians-Universität Würzburg DE Germany (DE) Helmholtz-Zentrum für Infektionsforschung (HZI) DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) Immunology Center of Marseille-Luminy FR France (FR) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) DE Germany (DE)

How to cite

APA:

Ataide, M.A., Knöpper, K., Cruz de Casas, P., Ugur, M., Eickhoff, S., Zou, M.,... Kastenmüller, W. (2022). Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes. Immunity, 55(10), 1813-1828.e9. https://dx.doi.org/10.1016/j.immuni.2022.07.019

MLA:

Ataide, Marco A., et al. "Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes." Immunity 55.10 (2022): 1813-1828.e9.

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