Immuncheckpoint Inhibitors: Current Indications and Possible Future Concepts Immuncheckpoint-Inhibitoren: Aktuelle Indikationen und mögliche zukünftige Konzepte

Schlaak M, Baues C, Trommer-Nestler M, Berking C, Belka C, Theurich S (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Deutsche Medizinische Wochenschrift Georg Thieme Verlag

Book Volume: 143

Pages Range: 1014-1021

Journal Issue: 14

DOI: 10.1055/s-0043-125001

Abstract

Immuno-oncological therapy concepts have already achieved great success in the treatment of a number of advanced malignancies, thereby rapidly gaining access to clinical practice. Immuncheckpoint inhibitors are also being reviewed in the adjuvant setting. In malignant melanoma, they have already shown efficacy. Different combination strategies of Immuncheckpoint inhibitors are currently undergoing clinical evaluation to further improve treatment outcomes. However, this has so far also been associated with a significantly increased immune-mediated rate of side effects. Effective and safe immuno-oncology requires good clinical management of immune-mediated side effects. Radiological assessment is challenging under immunotherapy and requires new standards (iRECIST). Encouraging is the fact that immunotherapy also causes long-term remissions in some of the patients. This raises the hope for a fundamentally curative potential of immuno-oncological therapeutic approaches.

Involved external institutions

Universitätsklinikum Köln DE Germany (DE) Klinikum der Universität München (Großhadern und Innenstadt) DE Germany (DE)

How to cite

APA:

Schlaak, M., Baues, C., Trommer-Nestler, M., Berking, C., Belka, C., & Theurich, S. (2018). Immuncheckpoint Inhibitors: Current Indications and Possible Future Concepts Immuncheckpoint-Inhibitoren: Aktuelle Indikationen und mögliche zukünftige Konzepte. Deutsche Medizinische Wochenschrift, 143(14), 1014-1021. https://dx.doi.org/10.1055/s-0043-125001

MLA:

Schlaak, Max, et al. "Immuncheckpoint Inhibitors: Current Indications and Possible Future Concepts Immuncheckpoint-Inhibitoren: Aktuelle Indikationen und mögliche zukünftige Konzepte." Deutsche Medizinische Wochenschrift 143.14 (2018): 1014-1021.

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