Supper M, Jost R, Bornschein B, Kaspereit M (2023)
Publication Type: Journal article, Original article
Publication year: 2023
Original Authors: Malvina Supper, Rosanna Jost, Benedikt Bornschein, Malte Kaspereit
Book Volume: 11
Article Number: 946
Issue: 3
DOI: 10.3390/pr11030946
The isolation of single homologs of polyethylene glycol by preparative reversed-phase chromatography is investigated. A thermodynamic model developed accurately previously describes the retention times of individual homologs as function of their size, temperature, and mobile phase composition under linear, diluted conditions. The model is extended to predict limiting retention times for linear gradient operation in preparative applications. Isocratic and gradient-based separations are studied under strongly overloaded conditions. Baseline separation of homologs up to 3000 g/mol is demonstrated. Quantitative production of pure single homologs up to molar weights of 1000 g/mol was performed using an automated setup.
APA:
Supper, M., Jost, R., Bornschein, B., & Kaspereit, M. (2023). Separation of Molar Weight-Distributed Polyethylene Glycols by Reversed-Phase Chromatography—II. Preparative Isolation of Pure Single Homologs. Processes, 11. https://doi.org/10.3390/pr11030946
MLA:
Supper, Malvina, et al. "Separation of Molar Weight-Distributed Polyethylene Glycols by Reversed-Phase Chromatography—II. Preparative Isolation of Pure Single Homologs." Processes 11 (2023).
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