Mechanical strength and intracellular uptake of CaCO3-templated LbL capsules composed of biodegradable polyelectrolytes: The influence of the number of layers

Palankar R, Pinchasik BE, Schmidt S, De Geest BG, Fery A, Moehwald H, Skirtach AG, Delcea M (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Journal of Materials Chemistry B Royal Society of Chemistry

Book Volume: 1

Pages Range: 1175-1181

Journal Issue: 8

DOI: 10.1039/c2tb00319h

Abstract

Developing carriers comprised of biomaterials and capable of withstanding significant mechanical pressures, structural deformations and at the same time delivering biomolecules is of high interest for drug delivery. Using colloidal probe AFM combined with quantitative fluorescence microscopy, we investigated mechanical properties and release from CaCO3-templated polymeric capsules made of biodegradable polymers. The mechanical and release properties of these capsules were studied in comparison with those of CaCO 3-templated capsules composed of synthetic polymers. Furthermore, we assessed the influence of the number of polyelectrolyte LbL layers on the mechanical properties and release from biodegradable capsules. Mechanical deformation of capsules was studied upon intracellular uptake of these capsules. Based on these results, we discuss implications for the design of microcapsules. © The Royal Society of Chemistry 2013.

Involved external institutions

Universität Greifswald DE Germany (DE) Max-Planck-Institut für Kolloid- und Grenzflächenforschung / Max Planck Institute of Colloids and Interfaces DE Germany (DE) Universiteit Gent (UGent) / Ghent University BE Belgium (BE) Universität Bayreuth DE Germany (DE)

How to cite

APA:

Palankar, R., Pinchasik, B.-E., Schmidt, S., De Geest, B.G., Fery, A., Moehwald, H.,... Delcea, M. (2013). Mechanical strength and intracellular uptake of CaCO3-templated LbL capsules composed of biodegradable polyelectrolytes: The influence of the number of layers. Journal of Materials Chemistry B, 1(8), 1175-1181. https://dx.doi.org/10.1039/c2tb00319h

MLA:

Palankar, Raghavendra, et al. "Mechanical strength and intracellular uptake of CaCO3-templated LbL capsules composed of biodegradable polyelectrolytes: The influence of the number of layers." Journal of Materials Chemistry B 1.8 (2013): 1175-1181.

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