Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions
Striegler C, Schumacher M, Effenberg C, Mueller M, Seckinger A, Schnettler R, Voit B, Hose D, Gelinsky M, Appelhans D (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 15
Pages Range: 1283-1295
Journal Issue: 9
Abstract
Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
Involved external institutions
Leibniz-Institut für Polymerforschung Dresden e. V.
Germany (DE)
Technische Universität Dresden
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Justus-Liebig-Universität Gießen
Germany (DE)
Germany (DE)
Technische Universität Dresden
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Justus-Liebig-Universität Gießen
Germany (DE)
How to cite
APA:
Striegler, C., Schumacher, M., Effenberg, C., Mueller, M., Seckinger, A., Schnettler, R.,... Appelhans, D. (2015). Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions. Macromolecular Bioscience, 15(9), 1283-1295. https://doi.org/10.1002/mabi.201500085
MLA:
Striegler, Christin, et al. "Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions." Macromolecular Bioscience 15.9 (2015): 1283-1295.
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