Graphene and other 2D materials: A multidisciplinary analysis to uncover the hidden potential as cancer theranostics
Fusco L, Gazzi A, Peng G, Shin Y, Vranic S, Bedognetti D, Vitale F, Yilmazer A, Feng X, Fadeel B, Casiraghi C, Delogu LG (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 10
Pages Range: 5435-5488
Journal Issue: 12
DOI: 10.7150/thno.40068
Abstract
Cancer represents one of the main causes of death in the world; hence the development of more specific approaches for its diagnosis and treatment is urgently needed in clinical practice. Here we aim at providing a comprehensive review on the use of 2-dimensional materials (2DMs) in cancer theranostics. In particular, we focus on graphene-related materials (GRMs), graphene hybrids, and graphdiyne (GDY), as well as other emerging 2DMs, such as MXene, tungsten disulfide (WS2), molybdenum disulfide (MoS2), hexagonal boron nitride (h-BN), black phosphorus (BP), silicene, antimonene (AM), germanene, biotite (black mica), metal organic frameworks (MOFs), and others. The results reported in the scientific literature in the last ten years (>200 papers) are dissected here with respect to the wide variety of combinations of imaging methodologies and therapeutic approaches, including drug/gene delivery, photothermal/photodynamic therapy, sonodynamic therapy, and immunotherapy. We provide a unique multidisciplinary approach in discussing the literature, which also includes a detailed section on the characterization methods used to analyze the material properties, highlighting the merits and limitations of the different approaches. The aim of this review is to show the strong potential of 2DMs for use as cancer theranostics, as well as to highlight issues that prevent the clinical translation of these materials. Overall, we hope to shed light on the hidden potential of the vast panorama of new and emerging 2DMs as clinical cancer theranostics.
Involved external institutions
Università degli Studi di Trieste
Italy (IT)
Karolinska Institute
Sweden (SE)
University of Manchester
United Kingdom (GB)
Sidra Medical and Research Center
Qatar (QA)
University of Pennsylvania
United States (USA) (US)
Ankara University / Ankara Üniversitesi
Turkey (TR)
Technische Universität Dresden
Germany (DE)
Fondazione Istituto di Ricerca Pediatrica Città della Speranza
Italy (IT)
Italy (IT)
Karolinska Institute
Sweden (SE)
University of Manchester
United Kingdom (GB)
Sidra Medical and Research Center
Qatar (QA)
University of Pennsylvania
United States (USA) (US)
Ankara University / Ankara Üniversitesi
Turkey (TR)
Technische Universität Dresden
Germany (DE)
Fondazione Istituto di Ricerca Pediatrica Città della Speranza
Italy (IT)
How to cite
APA:
Fusco, L., Gazzi, A., Peng, G., Shin, Y., Vranic, S., Bedognetti, D.,... Delogu, L.G. (2020). Graphene and other 2D materials: A multidisciplinary analysis to uncover the hidden potential as cancer theranostics. Theranostics, 10(12), 5435-5488. https://doi.org/10.7150/thno.40068
MLA:
Fusco, Laura, et al. "Graphene and other 2D materials: A multidisciplinary analysis to uncover the hidden potential as cancer theranostics." Theranostics 10.12 (2020): 5435-5488.
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