Thin-film microextraction using the metal-organic framework DUT-52 for determining endocrine disrupting chemicals in cosmetics
Gutierrez-Serpa A, Pasan J, Jimenez-Abizanda A, Kaskel S, Senkovska I, Pino V (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 181
Article Number: 107685
DOI: 10.1016/j.microc.2022.107685
Abstract
Metal-organic frameworks (MOFs)-based mixed-matrix membranes (MMMs) were used in a thin-film microextraction (TFME) method for the determination of six personal care products (PCPs) present in cosmetic samples, using ultra-high performance liquid chromatography coupled to a UV/Vis detector (UHPLC-UV/Vis). The type of MOF used (testing UiO-66, UiO-66-COOH, UiO-67, DUT-52, DUT-67, MOF-801, and MOF-808) in the MMM as well as the amount of MOF loaded (up to 60%, w/w) were optimized carefully to select the most adequate MOF-based MMMs for the analytical application. The type of exposure of the MOF-based MMM to the sample, the agitation mode, and the dimensions of the membranes, were also carefully evaluated. Besides, the main parameters affecting the TFME procedure were optimized by a Doehlert experimental design, dictating the following optimum conditions: the MOF DUT-52 MMMs presenting a 60% (w/w) of MOF loading, with membranes prepared using a 250 µm thickness as gap height (resulting in thicknesses of ∼ 60 µm once all solvents of the membranes are removed) and dimensions of 2 × 2 cm, 90 min of TFME time, a vortex assisted desorption step using 625 µL of acetonitrile (2 × times), and a further preconcentration to 150 µL. The entire method showed adequate analytical performance with limits of detection down to 0.030 ng·mL−1, and intra-day, inter-day, and inter-batch precision values (as RSD), better than 10%, 14%, and 20%, respectively, for a concentration level of 75 ng·mL−1. Three cosmetic samples were analyzed, with proper calibrations in the matrix, thus proving the stability and applicability with these matrices. Besides, a thorough study of the greenness of the method was assessed by application of the different existing metrics.
Involved external institutions
Spain (ES)
Germany (DE)How to cite
APA:
Gutierrez-Serpa, A., Pasan, J., Jimenez-Abizanda, A., Kaskel, S., Senkovska, I., & Pino, V. (2022). Thin-film microextraction using the metal-organic framework DUT-52 for determining endocrine disrupting chemicals in cosmetics. Microchemical Journal, 181. https://dx.doi.org/10.1016/j.microc.2022.107685
MLA:
Gutierrez-Serpa, Adrian, et al. "Thin-film microextraction using the metal-organic framework DUT-52 for determining endocrine disrupting chemicals in cosmetics." Microchemical Journal 181 (2022).
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