Encapsulation of Nanoparticles into Preformed Block Copolymer Micelles Driven by Competitive Solvation: Experimental Studies and Molecular Dynamic Simulations
Kumar L, Horechyy A, Paturej J, Nandan B, Klos JS, Sommer JU, Fery A (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 55
Pages Range: 9612-9626
Journal Issue: 21
DOI: 10.1021/acs.macromol.2c01388
Abstract
We investigate the encapsulation of polymer-tethered nanoparticles (NPs) inside block copolymer (BCP) micelles, which turns to the mutual stabilization of BCP micelles and NPs by each other. It has been demonstrated, for the first time, that in the presence of cosolvent, which is selective for the core-forming block, the encapsulation of polymer-tethered NPs into the core of preformed BCP micelles is feasible. Furthermore, interestingly, in a certain range of cosolvent volume fraction, NP/BCP hybrid micelles comprising a single NP in the micelle core could be obtained. Significantly, in the presence of cosolvent the NP-loaded hybrid micelles remain intact, whereas the NP-free (empty) micelles undergo further transformations. The experimental observations are additionally supported by the results obtained from the molecular dynamic simulation. In particular, our modeling recognizes mechanisms for the formation of NP/BCP hybrids, which include a one-by-one adsorption of individual BCP chains onto the NP surface, fusion of NP with the preformed BCP micelles, or a combination of both mechanisms. The present work provides new opportunities for the fabrication of BCP-based hybrid nanomaterials having potential applications in drug delivery, diagnostics, catalysis, energy harvesting materials, optical devices, etc.
Involved external institutions
Leibniz-Institut für Polymerforschung Dresden e. V.
Germany (DE)
Indian Institute of Technology (IIT), Delhi
India (IN)
Germany (DE)
Indian Institute of Technology (IIT), Delhi
India (IN)
How to cite
APA:
Kumar, L., Horechyy, A., Paturej, J., Nandan, B., Klos, J.S., Sommer, J.-U., & Fery, A. (2022). Encapsulation of Nanoparticles into Preformed Block Copolymer Micelles Driven by Competitive Solvation: Experimental Studies and Molecular Dynamic Simulations. Macromolecules, 55(21), 9612-9626. https://dx.doi.org/10.1021/acs.macromol.2c01388
MLA:
Kumar, Labeesh, et al. "Encapsulation of Nanoparticles into Preformed Block Copolymer Micelles Driven by Competitive Solvation: Experimental Studies and Molecular Dynamic Simulations." Macromolecules 55.21 (2022): 9612-9626.
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