Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex

Troscher AR, Mair KM, De Juan LV, Koeck U, Steinmaurer A, Baier H, Becker A, Blümcke I, Finzel M, Geis C, Hoftberger R, Mawrin C, Von Oertzen TJ, Pitsch J, Surges R, Voges B, Weis S, Winklehner M, Woermann F, Bauer J, Bien CG (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Brain Oxford University Press

DOI: 10.1093/brain/awac404

Abstract

Troscher et al. show that in patients with GAD65 antibody-associated temporal lobe epilepsy, cytotoxic T cells attack and kill neurons and are responsible for the early neuronal loss. Immunological treatment within the first few years may thus be necessary to prevent irreversible hippocampal damage.

Authors with CRIS profile

Ingmar Blümcke Lehrstuhl für Neuropathologie

Involved external institutions

Medizinische Universität Wien AT Austria (AT) Epilepsie-Zentrum Bodensee DE Germany (DE) Universitätsklinikum Bonn DE Germany (DE) Kleinwachau - Sächsisches Epilepsiezentrum Radeberg gGmbH DE Germany (DE) Universitätsklinikum Jena DE Germany (DE) Universitätsklinikum Magdeburg A.ö.R. DE Germany (DE) Kepler Universitätsklinikum (KUK) AT Austria (AT) Universität Bielefeld DE Germany (DE) Evangelisches Krankenhaus Alsterdorf DE Germany (DE)

How to cite

APA:

Troscher, A.R., Mair, K.M., De Juan, L.V., Koeck, U., Steinmaurer, A., Baier, H.,... Bien, C.G. (2022). Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex. Brain. https://doi.org/10.1093/brain/awac404

MLA:

Troscher, Anna R., et al. "Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex." Brain (2022).

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