Chemical Constituents from Streblus taxoides Wood with Their Antibacterial and Antityrosinase Activities Plus in Silico Study

Parndaeng K, Pitakbut T, Wattanapiromsakul C, Hwang JS, Udomuksorn W, Dej-Adisai S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Antibiotics MDPI

Book Volume: 12

Article Number: 319

Journal Issue: 2

DOI: 10.3390/antibiotics12020319

Abstract

Hyperpigmentation frequently occurs after inflammation from bacterial infection. Thus, the inhibition activity of tyrosinase, the key enzyme to catalyze the melanogenesis and/or inhibition of bacterial infection, could decrease melanin production. Hence, the potential inhibitors could be discovered from natural products. ω-Hydroxymoracin C (1), a new compound with two other 2-arylbenzofurans, i.e., moracin M (2) and moracin C (3), and two stilbenes, i.e., 3, 4, 3’, 5′-tetrahydroxybibenzyl (4) and piceatannol (5), were isolated from the wood of Streblus taxoides. Compound 4 showed a strong inhibitory activity against tyrosinase enzyme with an IC50 value of 35.65 µg/mL, followed by compound 2 with an IC50 value of 47.34 µg/mL. Conversely, compound 1, 3 and 5 showed moderate activity, with IC50 values of 109.64, 128.67 and 149.73 µg/mL, respectively. Moreover, compound 1 and 3 showed an antibacterial effect against some Staphylococcus spp. Thus, the isolated compounds exhibited potential antityrosine and antibacterial effects. Additionally, an in silico study was performed in order to predict theoretical molecular interactions between the obtained metabolites from S. taxoides and tyrosinase as an extended in vitro enzyme binding assay experiment.

Authors with CRIS profile

Thanet Pitakbut Lehrstuhl für Pharmazeutische Biologie

Involved external institutions

Prince of Songkla University, PSU TH Thailand (TH) Kyung Hee University KR Korea, Republic of (KR)

How to cite

APA:

Parndaeng, K., Pitakbut, T., Wattanapiromsakul, C., Hwang, J.S., Udomuksorn, W., & Dej-Adisai, S. (2023). Chemical Constituents from Streblus taxoides Wood with Their Antibacterial and Antityrosinase Activities Plus in Silico Study. Antibiotics, 12(2). https://doi.org/10.3390/antibiotics12020319

MLA:

Parndaeng, Kedsaraporn, et al. "Chemical Constituents from Streblus taxoides Wood with Their Antibacterial and Antityrosinase Activities Plus in Silico Study." Antibiotics 12.2 (2023).

BibTeX: Download