Pulmonary emphysema diagnosis with a preclinical small-animal x-ray dark-field scatter-contrast scanner
Yaroshenko A, Meinel FG, Bech M, Tapfer A, Velroyen A, Schleede S, Auweter S, Bohla A, Yildirim AO, Nikolaou K, Bamberg F, Eickelberg O, Reiser MF, Pfeiffer F (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 269
Pages Range: 427-433
Journal Issue: 2
Abstract
Purpose: To test the hypothesis that the joint distribution of x-ray transmission and dark-field signals obtained with a compact cone-beam preclinical scanner with a polychromatic source can be used to diagnose pulmonary emphysema in ex vivo murine lungs. Materials and Methods: The animal care committee approved this study. Three excised murine lungs with pulmonary emphysema and three excised murine control lungs were imaged ex vivo by using a grating-based micro-computed tomographic (CT) scanner. To evaluate the diagnostic value, the natural logarithm of relative transmission and the natural logarithm of darkfield scatter signal were plotted on a per-pixel basis on a scatterplot. Probability density function was fit to the joint distribution by using principle component analysis. An emphysema map was calculated based on the fitted probability density function. Results: The two-dimensional scatterplot showed a characteristic difference between control and emphysematous lungs. Control lungs had lower average median logarithmic transmission (-0.29 vs -0.18, P =.1) and lower average dark-field signal (-0.54 vs -0.37, P =.1) than emphysematous lungs. The angle to the vertical axis of the fitted regions also varied significantly (7.8° for control lungs vs 15.9° for emphysematous lungs). The calculated emphysema distribution map showed good agreement with histologic findings. Conclusion: X-ray dark-field scatter images of murine lungs obtained with a preclinical scanner can be used in the diagnosis of pulmonary emphysema. © RSNA, 2013.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
How to cite
APA:
Yaroshenko, A., Meinel, F.G., Bech, M., Tapfer, A., Velroyen, A., Schleede, S.,... Pfeiffer, F. (2013). Pulmonary emphysema diagnosis with a preclinical small-animal x-ray dark-field scatter-contrast scanner. Radiology, 269(2), 427-433. https://doi.org/10.1148/radiol.13122413
MLA:
Yaroshenko, Andre, et al. "Pulmonary emphysema diagnosis with a preclinical small-animal x-ray dark-field scatter-contrast scanner." Radiology 269.2 (2013): 427-433.
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