Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

Clerx L, Van Rossum IA, Burns L, Knol DL, Scheltens P, Verhey F, Aalten P, Lapuerta P, Van De Pol L, Van Schijndel R, De Jong R, Barkhof F, Wolz R, Rueckert D, Bocchetta M, Tsolaki M, Nobili F, Wahlund LO, Minthon L, Froelich L, Hampel H, Soininen H, Visser PJ (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Neurobiology of Aging Elsevier

Book Volume: 34

Pages Range: 2003-2013

Journal Issue: 8

DOI: 10.1016/j.neurobiolaging.2013.02.002

Abstract

Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (. n = 156) and the single-center VU medical center (. n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI. © 2013 Elsevier Inc.

Involved external institutions

Maastricht University NL Netherlands (NL) Vrije Universiteit Amsterdam (VU) / University Amsterdam NL Netherlands (NL) Bristol-Myers Squibb GmbH & Co. KGaA DE Germany (DE) Lexicon Pharmaceuticals, Inc. US United States (USA) (US) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) Centro San Giovanni di Dio Fatebenefratelli IT Italy (IT) Aristotle University of Thessaloniki GR Greece (GR) University of Genova / Università degli Studi di Genova IT Italy (IT) Karolinska University Hospital / Karolinska Universitetssjukhuset SE Sweden (SE) Lund University / Lunds universitet SE Sweden (SE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) University of Eastern Finland FI Finland (FI)

How to cite

APA:

Clerx, L., Van Rossum, I.A., Burns, L., Knol, D.L., Scheltens, P., Verhey, F.,... Visser, P.J. (2013). Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment. Neurobiology of Aging, 34(8), 2003-2013. https://doi.org/10.1016/j.neurobiolaging.2013.02.002

MLA:

Clerx, Lies, et al. "Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment." Neurobiology of Aging 34.8 (2013): 2003-2013.

BibTeX: Download