Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Calzolari F, Michel J, Baumgart EV, Theis F, Goetz M, Ninkovic J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Nature Neuroscience Nature Publishing Group

Book Volume: 18

Pages Range: 490-492

Journal Issue: 4

DOI: 10.1038/nn.3963

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE)

How to cite

APA:

Calzolari, F., Michel, J., Baumgart, E.V., Theis, F., Goetz, M., & Ninkovic, J. (2015). Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone. Nature Neuroscience, 18(4), 490-492. https://dx.doi.org/10.1038/nn.3963

MLA:

Calzolari, Filippo, et al. "Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone." Nature Neuroscience 18.4 (2015): 490-492.

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