Grating-based X-ray Dark-field Computed Tomography of Living Mice
Velroyen A, Yaroshenko A, Hahn D, Fehringer A, Tapfer A, Mueller M, Noel PB, Pauwels B, Sasov A, Yildirim AO, Eickelberg O, Hellbach K, Auweter SD, Meinel FG, Reiser MF, Bech M, Pfeiffer F (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 2
Pages Range: 1500-1506
Journal Issue: 10
DOI: 10.1016/j.ebiom.2015.08.014
Abstract
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Bruker Belgium S.A./N.V.
Belgium (BE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Germany (DE)
Bruker Belgium S.A./N.V.
Belgium (BE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
How to cite
APA:
Velroyen, A., Yaroshenko, A., Hahn, D., Fehringer, A., Tapfer, A., Mueller, M.,... Pfeiffer, F. (2015). Grating-based X-ray Dark-field Computed Tomography of Living Mice. EBioMedicine, 2(10), 1500-1506. https://doi.org/10.1016/j.ebiom.2015.08.014
MLA:
Velroyen, A., et al. "Grating-based X-ray Dark-field Computed Tomography of Living Mice." EBioMedicine 2.10 (2015): 1500-1506.
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