Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease
Schneider S, Koch W, Hoppmann P, Ubrich R, Kemmner S, Steinlechner E, Heemann U, Laugwitz KL, Kastrati A, Baumann M (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 12
Article Number: 4
Journal Issue: 1
DOI: 10.1186/s12979-015-0031-2
Abstract
Background: Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence that Toll-like receptor 4 (TLR4) modulate inflammation and contribute to age-dependent SBP increase. However, there are no data about TLR4 and age-dependent blood pressure increase in human. Methods and results: We therefor investigate a human cohort of 2679 patients with CAD aged between 50-80 years. Genotypes were determined for the TLR4 single nucleotide polymorphism rs4986790 (TLR4 896A/G). Patients were stratified according to tertiles of age and the upper tertile was compared to lower tertiles. In this cohort we show that older patients with the TLR4 896 G allele had significantly lower SBP (TLR4 G allele carriers: 148.2 ± 30.4 mmHg versus A/A allele carrier: 154.9 ± 27.2 mmHg; P < 0.05) and lower pulse pressure (TLR4 G allele carriers: 69.1 ± 29.7 mmHg versus A/A allele carrier: 75.5 ± 26.4 mmHg; P < 0.05) as compared to TLR4 896A/A allele carrier. Conclusion: We demonstrate an association between the TLR4 SNP rs4986790 genotype and age-dependant blood pressure increase in patients with coronary artery disease.
Involved external institutions
Germany (DE)How to cite
APA:
Schneider, S., Koch, W., Hoppmann, P., Ubrich, R., Kemmner, S., Steinlechner, E.,... Baumann, M. (2015). Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease. Immunity & Ageing, 12(1). https://dx.doi.org/10.1186/s12979-015-0031-2
MLA:
Schneider, Simon, et al. "Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease." Immunity & Ageing 12.1 (2015).
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