Advancing surgical vision with fluorescence imaging
Koch M, Ntziachristos V (2016)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2016
Journal
Publisher: Annual Reviews Inc.
Series: Annual Review of Medicine
City/Town: Palo Alto
Book Volume: 67
Pages Range: 153-164
DOI: 10.1146/annurev-med-051914-022043
Abstract
Surgical success depends on the accuracy with which disease and vital tissue can be intraoperatively detected. However, the dominant visualization approach, i.e., human vision, does not see under the tissue surface and operates on low contrast between sites of disease, such as cancer, and the surrounding tissue. Intraoperative fluorescence imaging is emerging as a highly effective method to improve surgical vision and offers the potential to be intergrated seamlessly into the normal workflow of the operating room without causing disruption or undue delay. We review and compare two critical fluorescence imaging directions: one that uses nonspecific fluorescence dyes, addressing tissue perfusion and viability, and one that uses targeted agents, interrogating pathophysiological features of disease. These two approaches present detection sensitivity challenges that may differ by orders of magnitude and require different detection strategies. Nevertheless, fluorescence imaging provides the surgeon with previously unavailable real-time feedback that improves surgical precision and can become essential for interventional decision-making.
Involved external institutions
Germany (DE)How to cite
APA:
Koch, M., & Ntziachristos, V. (2016). Advancing surgical vision with fluorescence imaging. In (pp. 153-164). Palo Alto: Annual Reviews Inc..
MLA:
Koch, Maximilian, and Vasilis Ntziachristos. "Advancing surgical vision with fluorescence imaging." Palo Alto: Annual Reviews Inc., 2016. 153-164.
BibTeX: Download