Wavelength-Modulated Differential Photoacoustic Spectroscopy (WM-DPAS) for noninvasive early cancer detection and tissue hypoxia monitoring

Choi SS, Mandelis A, Guo X, Lashkari B, Kellnberger S, Ntziachristos V (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Biophotonics Wiley-VCH Verlag

Book Volume: 9

Pages Range: 388-395

Journal Issue: 4

DOI: 10.1002/jbio.201500131

Abstract

This study introduces a novel noninvasive differential photoacoustic method, Wavelength Modulated Differential Photoacoustic Spectroscopy (WM-DPAS), for noninvasive early cancer detection and continuous hypoxia monitoring through ultrasensitive measurements of hemoglobin oxygenation levels (StO2). Unlike conventional photoacoustic spectroscopy, WM-DPAS measures simultaneously two signals induced from square-wave modulated laser beams at two different wavelengths where the absorption difference between maximum deoxy- and oxy-hemoglobin is 680 nm, and minimum (zero) 808 nm (the isosbestic point). The two-wavelength measurement efficiently suppresses background, greatly enhances the signal to noise ratio and thus enables WM-DPAS to detect very small changes in total hemoglobin concentration (CHb) and oxygenation levels, thereby identifying pre-malignant tumors before they are anatomically apparent. The non-invasive nature also makes WM-DPAS the best candidate for ICU bedside hypoxia monitoring in stroke patients. Sensitivity tunability is another special feature of the technology: WM-DPAS can be tuned for different applications such as quick cancer screening and accurate StO2 quantification by selecting a pair of parameters, signal amplitude ratio and phase shift. The WM-DPAS theory has been validated with sheep blood phantom measurements.

Involved external institutions

University of Toronto CA Canada (CA) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Choi, S.S., Mandelis, A., Guo, X., Lashkari, B., Kellnberger, S., & Ntziachristos, V. (2016). Wavelength-Modulated Differential Photoacoustic Spectroscopy (WM-DPAS) for noninvasive early cancer detection and tissue hypoxia monitoring. Journal of Biophotonics, 9(4), 388-395. https://doi.org/10.1002/jbio.201500131

MLA:

Choi, Sung Soo (Sean), et al. "Wavelength-Modulated Differential Photoacoustic Spectroscopy (WM-DPAS) for noninvasive early cancer detection and tissue hypoxia monitoring." Journal of Biophotonics 9.4 (2016): 388-395.

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