Gamma-glutamyl transferase and prognosis in patients with coronary artery disease
Ndrepepa G, Braun S, Schunkert H, Laugwitz KL, Kastrati A (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 452
Pages Range: 155-160
DOI: 10.1016/j.cca.2015.11.013
Abstract
Background: The association between gamma-glutamyl transferase (GGT) activity and outcome of patients with coronary artery disease (CAD) remains poorly investigated. Methods: The study included 5501 patients with CAD treated with percutaneous coronary intervention and GGT measurements available. The primary outcome was 3-year mortality. Results: GGT activity tertiles were: 1st tertile (GGT < 28.10 U/L; n = 1866), 2nd tertile (GGT ≥ 28.10 U/L to 49.50 U/L; n = 1804) and 3rd tertile (GG > 49.50 U/L; n = 1831). There were 110 deaths in the 1st, 111 deaths in the 2nd and 216 deaths in the 3rd GGT tertile (mortality estimates, 7.1%, 7.2% and 13.9%; P < 0.001). GGT was independently associated with the increased risk of 3-year all-cause (adjusted hazard ratio [HR] = 1.30, 95% confidence interval [CI] 1.18 to 1.44, P < 0.001), cardiac (HR = 1.21 [1.06-1.39], P = 0.005) and non-cardiac (HR = 1.42 [1.23-1.63], P < 0.001) mortality (all risk estimates calculated per standard deviation increase in the log GGT activity). GGT improved prediction of all-cause (P < 0.001) and non-cardiac mortality (P < 0.001) but not cardiac mortality (P = 0.155). Conclusions: In patients with CAD, elevated GGT activity is associated with increased risk of 3-year all-cause, cardiac and non-cardiac mortality. GGT provided incremental prognostic information on top of cardiovascular and metabolic risk factors for prediction of all-cause and non-cardiac mortality but not cardiac mortality.
Involved external institutions
Germany (DE)How to cite
APA:
Ndrepepa, G., Braun, S., Schunkert, H., Laugwitz, K.-L., & Kastrati, A. (2016). Gamma-glutamyl transferase and prognosis in patients with coronary artery disease. Clinica Chimica Acta, 452, 155-160. https://doi.org/10.1016/j.cca.2015.11.013
MLA:
Ndrepepa, Gjin, et al. "Gamma-glutamyl transferase and prognosis in patients with coronary artery disease." Clinica Chimica Acta 452 (2016): 155-160.
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