Prognostic Value of High-sensitivity Troponin T After Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease Valor pronóstico de la troponina T de alta sensibilidad tras intervención coronaria percutánea en pacientes con enfermedad coronaria estable
Ndrepepa G, Braun S, Cassese S, Mayer K, Lohaus R, Lahmann AL, Fusaro M, Laugwitz KL, Schunkert H, Kastrati A (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 69
Pages Range: 746-753
Journal Issue: 8
DOI: 10.1016/j.recesp.2016.02.023
Abstract
Introduction and objectives The prognostic value of high-sensitivity troponin T after percutaneous coronary intervention in patients with stable coronary artery disease is unclear. We investigated this clinically relevant question in 3463 consecutive patients undergoing percutaneous coronary intervention. Methods This study included patients with stable coronary artery disease and baseline high-sensitivity troponin T below the 99th percentile upper reference limit (0.014 μg/L). High-sensitivity troponin T was measured before and at 6, 12 and 24 hours after the procedure. The primary outcome was all-cause mortality. Results Patients were divided into a group with peak postprocedural troponin T ≤ 99th percentile (n = 742), a group with peak postprocedural troponin T > 99th to 5 × 99th percentile (n = 1928), and a group with peak postprocedural troponin T > 5 × 99th percentile upper reference limit (n = 793). Advanced age, smaller body mass index, baseline troponin level, complex lesions, bifurcation lesions and stented length were independently associated with elevated troponin T levels after the procedure. The median follow-up was 15.5 months. There were 56 deaths: 5 deaths (1.7%) among patients with peak postprocedural troponin T ≤ 99th percentile, 35 deaths (4.5%) among patients with peak postprocedural troponin T > 99th to 5 × 99th percentile and 16 deaths (4.3%) among patients with peak postprocedural troponin T > 5 × 99th percentile upper reference limit (hazard ratio = 1.50; 95% confidence interval, 1.01-2.25; P = .047). After adjustment, peak postprocedural troponin T level was not independently associated with mortality after percutaneous coronary intervention (P = .094). Conclusions In patients with stable coronary artery disease and without elevated baseline high-sensitivity troponin T, elevated high-sensitivity troponin T level after percutaneous coronary intervention was not associated with postprocedural mortality. Full English text available from: www.revespcardiol.org/en
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APA:
Ndrepepa, G., Braun, S., Cassese, S., Mayer, K., Lohaus, R., Lahmann, A.L.,... Kastrati, A. (2016). Prognostic Value of High-sensitivity Troponin T After Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease Valor pronóstico de la troponina T de alta sensibilidad tras intervención coronaria percutánea en pacientes con enfermedad coronaria estable. Revista Espanola De Cardiologia, 69(8), 746-753. https://doi.org/10.1016/j.recesp.2016.02.023
MLA:
Ndrepepa, Gjin, et al. "Prognostic Value of High-sensitivity Troponin T After Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease Valor pronóstico de la troponina T de alta sensibilidad tras intervención coronaria percutánea en pacientes con enfermedad coronaria estable." Revista Espanola De Cardiologia 69.8 (2016): 746-753.
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