Influence of high polyphenol beverage on stress-induced platelet activation

Nickel T, Lackermair K, Scherr J, Calatzis A, Vogeser M, Hanssen H, Waidhauser G, Schoenermark U, Methe H, Horster S, Wilbert-Lampen U, Halle M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Nutrition, Health & Aging Springer Verlag

Book Volume: 20

Pages Range: 586-593

Journal Issue: 6

DOI: 10.1007/s12603-016-0697-y

Abstract

Objectives: Platelets are playing a crucial role in acute cardiovascular events. We investigated if physical stress activates platelets and whether this activation can be inhibited by a polyphenol-enriched diet. Methods: Blood samples were taken from a total of 103 athletes three weeks before, one day before, immediately as well as 24 hours and 72 hours after a marathon run. Participants were randomized, double-blinded and divided into two groups. One group received a polyphenol-rich beverage the other the same beverage without polyphenols. Besides analysis of platelet counts and impedance-aggregometric-measurement of platelet activity, soluble P-selectin and Endothelin-A measurements were performed. Results: In the control group, runners showed a 2.2-fold increased platelet aggregation directly after completing a marathon and within the following three days when compared with baseline values (p<0.01). In accordance, significant increases in sP-selectin (57.52ng/ml vs. 94.86ng/ml;p<0.01) were detectable. In contrast, for the group consuming a beverage with increased polyphenol content (upper quartile of study beverage intake) we did not find any increase of platelet aggregation. Discussion: Physical stress causes a significant increase in platelet activity. Our results demonstrate that a diet enriched in polyphenols is capable of preventing platelet activation. These findings might indicate a diminished cardiovascular stress-reaction following pre-exposition to polyphenol-enriched diet.

Involved external institutions

Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Universität Basel CH Switzerland (CH)

How to cite

APA:

Nickel, T., Lackermair, K., Scherr, J., Calatzis, A., Vogeser, M., Hanssen, H.,... Halle, M. (2016). Influence of high polyphenol beverage on stress-induced platelet activation. Journal of Nutrition, Health & Aging, 20(6), 586-593. https://dx.doi.org/10.1007/s12603-016-0697-y

MLA:

Nickel, T., et al. "Influence of high polyphenol beverage on stress-induced platelet activation." Journal of Nutrition, Health & Aging 20.6 (2016): 586-593.

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