Mono-Energy Coronary Angiography with a Compact Synchrotron Source
Eggl E, Mechlem K, Braig E, Kulpe S, Dierolf M, Guenther B, Achterhold K, Herzen J, Gleich B, Rummeny E, Noel PB, Pfeiffer F, Muenzel D (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 7
Article Number: 42211
DOI: 10.1038/srep42211
Abstract
X-ray coronary angiography is an invaluable tool for the diagnosis of coronary artery disease. However, the use of iodine-based contrast media can be contraindicated for patients who present with chronic renal insufficiency or with severe iodine allergy. These patients could benefit from a reduced contrast agent concentration, possibly achieved through application of a mono-energetic x-ray beam. While large-scale synchrotrons are impractical for daily clinical use, the technology of compact synchrotron sources strongly advanced during the last decade. Here we present a quantitative analysis of the benefits a compact synchrotron source can offer in coronary angiography. Simulated projection data from quasi-mono-energetic and conventional x-ray tube spectra is used for a CNR comparison. Results show that compact synchrotron spectra would allow for a significant reduction of contrast media. Experimentally, we demonstrate the feasibility of coronary angiography at the Munich Compact Light Source, the first commercial installation of a compact synchrotron source.
Involved external institutions
Germany (DE)How to cite
APA:
Eggl, E., Mechlem, K., Braig, E., Kulpe, S., Dierolf, M., Guenther, B.,... Muenzel, D. (2017). Mono-Energy Coronary Angiography with a Compact Synchrotron Source. Scientific Reports, 7. https://doi.org/10.1038/srep42211
MLA:
Eggl, Elena, et al. "Mono-Energy Coronary Angiography with a Compact Synchrotron Source." Scientific Reports 7 (2017).
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