Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease
Ndrepepa G, Xhepa E, Colleran R, Braun S, Cassese S, Fusaro M, Laugwitz KL, Kastrati A (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 465
Pages Range: 17-21
DOI: 10.1016/j.cca.2016.12.003
Abstract
Background The association between gamma-glutamyl transferase (GGT) and atrial fibrillation (AF) in patients with coronary artery disease (CAD) is uncertain. Methods This study included 5501 consecutive patients with CAD, all of whom had baseline GGT measurements available. The primary endpoint was presence of AF. Results Overall 809 patients (14.7%) had AF on hospital admission. Patients with AF had significantly higher GGT activity compared with patients in sinus rhythm (median [25th–75th percentile]: 52.0 [32.9–96.0] U/L versus 34.8 [23.8–55.9] U/L, P < 0.001). The prevalence of AF increased from 8.6% of patients in the first GGT decile to 30.3% of patients in the tenth decile (P < 0.001). After multivariable adjustment, GGT activity remained independently associated with the probability of the presence of AF (adjusted adds ratio = 1.66, 95% confidence interval 1.53–1.81, P < 0.001 for each standard deviation increment in the GGT logarithmic scale). GGT predicted the probability of AF with an area under the receiver operating characteristic (ROC) curve of 0.6496, 95% confidence interval 0.6287 to 0.6705, P < 0.001 indicating moderate strength to discriminate between patients with and without AF. Conclusions In patients with CAD, elevated GGT activity is independently associated with the presence of AF. GGT may be a circulating marker of the risk for AF.
Involved external institutions
Germany (DE)How to cite
APA:
Ndrepepa, G., Xhepa, E., Colleran, R., Braun, S., Cassese, S., Fusaro, M.,... Kastrati, A. (2017). Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease. Clinica Chimica Acta, 465, 17-21. https://doi.org/10.1016/j.cca.2016.12.003
MLA:
Ndrepepa, Gjin, et al. "Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease." Clinica Chimica Acta 465 (2017): 17-21.
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