Outcomes of patients treated with durable polymer platinumchromium everolimus-eluting stents: A meta-analysis of randomised trials
Cassese S, Ndrepepa G, Byrne RA, Kufner S, Xhepa E, De Waha A, Rheude T, Colleran R, Giacoppo D, Harada Y, Laugwitz KL, Schunkert H, Fusaro M, Kastrati A (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 13
Pages Range: 986-993
Journal Issue: 8
Abstract
Aims: The durable polymer platinum-chromium everolimus-eluting stent (PtCr-EES) is a new-generation drug-eluting stent (DES) with a platinum-enriched metallic platform developed to improve the percutaneous treatment of patients with coronary artery disease. We sought to investigate the performance of durable polymer PtCr-EES versus other new-generation DES. Methods and results: We undertook a meta-analysis of trials in which patients receiving percutaneous coronary intervention (PCI) were randomly assigned to durable polymer PtCr-EES versus other new-generation DES (other DES). Primary efficacy and safety outcomes were target lesion revascularisation (TLR) and definite/probable stent thrombosis (ST), respectively. Secondary outcomes were myocardial infarction (MI), target vessel revascularisation (TVR), death, cardiac death and longitudinal stent deformation (LSD). A total of 11, 036 patients in seven trials received a PCI with either durable polymer PtCr-EES (n=6, 613) or other DES (n=4, 423). This latter group comprised patients treated with biolimus- (n=325), cobalt-chromium everolimus- (n=1, 940) or zotarolimus-eluting stents (n=2, 158). After a median follow-up of 12 months (interquartile range 12-24), durable polymer PtCr-EES displayed a risk of TLR (odds ratio 0.98, 95% confidence interval [CI]: 0.75-1.29; p=0.90) and definite/probable ST (0.89 [0.55-1.45]; p=0.63) comparable to that of other DES. However, the durable polymer PtCr-EES was associated with a higher risk of LSD (12.05 [1.60-90.71], p=0.02) compared to other DES. There was no significant difference with regard to other secondary outcomes nor was there heterogeneity across trials. Conclusions: At one-year follow-up, the durable polymer PtCr-EES displays a performance comparable to that of other new-generation DES platforms.
Involved external institutions
Germany (DE)How to cite
APA:
Cassese, S., Ndrepepa, G., Byrne, R.A., Kufner, S., Xhepa, E., De Waha, A.,... Kastrati, A. (2017). Outcomes of patients treated with durable polymer platinumchromium everolimus-eluting stents: A meta-analysis of randomised trials. EuroIntervention, 13(8), 986-993. https://doi.org/10.4244/EIJ-D-16-00871
MLA:
Cassese, Salvatore, et al. "Outcomes of patients treated with durable polymer platinumchromium everolimus-eluting stents: A meta-analysis of randomised trials." EuroIntervention 13.8 (2017): 986-993.
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