Evaluating combinations of diagnostic tests to discriminate different dementia types

Bruun M, Rhodius-Meester HF, Koikkalainen J, Baroni M, Gjerum L, Lemstra AW, Barkhof F, Remes AM, Urhemaa T, Tolonen A, Rueckert D, van Gils M, Frederiksen KS, Waldemar G, Scheltens P, Mecocci P, Soininen H, Lötjönen J, Hasselbalch SG, van der Flier WM (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring Wiley

Book Volume: 10

Pages Range: 509-518

DOI: 10.1016/j.dadm.2018.07.003

Abstract

Introduction: We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia. Methods: In this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal dementia, 61 dementia with Lewy bodies, 38 vascular dementia, and 302 controls. We used a classifier to assess accuracy for individual performance and combinations of cognitive tests, cerebrospinal fluid biomarkers, and automated magnetic resonance imaging features for pairwise differentiation between dementia types. Results: Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78% to 97%. Discussion: Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.

Involved external institutions

University of Copenhagen DK Denmark (DK) Alzheimercentrum Amsterdam NL Netherlands (NL) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra NL Netherlands (NL) Oulu University Hospital FI Finland (FI) VTT Technical Research Centre of Finland FI Finland (FI) Combinostics Oy FI Finland (FI) Università degli Studi di Perugia IT Italy (IT) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) University of Eastern Finland FI Finland (FI)

How to cite

APA:

Bruun, M., Rhodius-Meester, H.F., Koikkalainen, J., Baroni, M., Gjerum, L., Lemstra, A.W.,... van der Flier, W.M. (2018). Evaluating combinations of diagnostic tests to discriminate different dementia types. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 10, 509-518. https://doi.org/10.1016/j.dadm.2018.07.003

MLA:

Bruun, Marie, et al. "Evaluating combinations of diagnostic tests to discriminate different dementia types." Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring 10 (2018): 509-518.

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