Multispectral optoacoustic tomography of benign and malignant thyroid disorders: A pilot study
Roll W, Markwardt NA, Masthoff M, Helfen A, Claussen J, Eisenblaetter M, Hasenbach A, Hermann S, Karlas A, Wildgruber M, Ntziachristos V, Schaefers M (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 60
Pages Range: 1461-1466
Journal Issue: 10
DOI: 10.2967/jnumed.118.222174
Abstract
This study aimed at evaluating hybrid multispectral optoacoustic tomography/ultrasound for imaging of thyroid disorders, including Graves' disease and thyroid nodules. Methods: The functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin, saturation of hemoglobin, fat content, and water content were analyzed in thyroid lobes affected by Graves' disease (n 5 6), thyroid lobes with healthy tissue (n 5 8), benign thyroid nodules (n 5 13), and malignant thyroid nodules (n 5 3). Results: In Graves' disease, significantly higher deoxygenated hemoglobin (3.18 ± 0.52 vs. 2.13 ± 0.62; P 5 0.0055) and total hemoglobin (8.34 ± 0.88 vs. 6.59 ± 1.16; P 5 0.0084) and significantly lower fat content (0.64 ± 0.37 vs. 1.69 ± 1.25; P 5 0.0293) were found than in healthy controls. Malignant thyroid nodules showed significantly lower saturation of hemoglobin (55.4% ± 2.6% vs. 60.8% ± 7.2%; P 5 0.0393) and lower fat content (0.62 ± 0.19 vs. 1.46 ± 0.87; P 5 0.1295) than benign nodules. Conclusion: This pilot study showed the applicability and the potential of hybrid multispectral optoacoustic tomography/ultrasound to semiquantitatively provide tissue characterization and functional parameters in thyroid disorders for improved noninvasive diagnostics of thyroid diseases.
Involved external institutions
iThera Medical GmbH
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
How to cite
APA:
Roll, W., Markwardt, N.A., Masthoff, M., Helfen, A., Claussen, J., Eisenblaetter, M.,... Schaefers, M. (2019). Multispectral optoacoustic tomography of benign and malignant thyroid disorders: A pilot study. Journal of Nuclear Medicine, 60(10), 1461-1466. https://doi.org/10.2967/jnumed.118.222174
MLA:
Roll, Wolfgang, et al. "Multispectral optoacoustic tomography of benign and malignant thyroid disorders: A pilot study." Journal of Nuclear Medicine 60.10 (2019): 1461-1466.
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