SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 26
Pages Range: 681-687
Journal Issue: 5
DOI: 10.1038/s41591-020-0868-6
Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
Involved external institutions
Wellcome Trust Sanger Institute - Genome Research Limited
United Kingdom (GB)
University of Côte d'Azur / Université Côte d'Azur
France (FR)
University of Groningen / Rijksuniversiteit Groningen
Netherlands (NL)
Newcastle University
United Kingdom (GB)
Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Germany (DE)
Harvard University
United States (USA) (US)
University College London (UCL)
United Kingdom (GB)
University of Cambridge
United Kingdom (GB)
United Kingdom (GB)
University of Côte d'Azur / Université Côte d'Azur
France (FR)
University of Groningen / Rijksuniversiteit Groningen
Netherlands (NL)
Newcastle University
United Kingdom (GB)
Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Germany (DE)
Harvard University
United States (USA) (US)
University College London (UCL)
United Kingdom (GB)
University of Cambridge
United Kingdom (GB)
How to cite
APA:
Sungnak, W., Huang, N., Becavin, C., Berg, M., Queen, R., Litvinukova, M.,... Barnes, J.L. (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine, 26(5), 681-687. https://doi.org/10.1038/s41591-020-0868-6
MLA:
Sungnak, Waradon, et al. "SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes." Nature Medicine 26.5 (2020): 681-687.
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