Quantitative 3d assessment of 68ga-dotatoc pet/mri with diffusion-weighted imaging to assess imaging markers for gastroenteropancreatic neuroendocrine tumors: Preliminary results
Adams LC, Bressem KK, Brangsch J, Reimann C, Nowak K, Brenner W, Makowski MR (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 61
Pages Range: 1021-1027
Journal Issue: 7
DOI: 10.2967/jnumed.119.234062
Abstract
68Ga-DOTATOC PET/MRI combines the advantages of PET in the acquisition of metabolic-functional information with the high softtissue contrast of MRI. SUVs in tumors have been suggested to be a measure of somatostatin receptor expression. A challenge with receptor ligands is that the distribution volume is confined to tissues with tracer uptake, potentially limiting SUV quantification. In this study, various functional 3-dimensional SUV apparent diffusion coefficient (ADC) parameters and arterial tumor enhancement were tested for ability to characterize gastroenteropancreatic (GEP) neuroendocrine tumors (NETs). Methods: For this single-center, crosssectional study, 22 patients with 24 histologically confirmed GEP NET lesions (15 men and 7 women; median age, 61 y; range, 43- 81 y) who underwent hybrid 68Ga-DOTA PET/MRI at 3 T between January 2017 and July 2019 met the eligibility criteria. SUV, tumorto- background ratio, total functional tumor volume, and mean and minimum ADC were measured on the basis of volumes of interest and examined with receiver-operating-characteristic analysis to determine cutoffs for differentiation between low- and intermediategrade GEP NETs. The Spearman rank correlation coefficient was used to assess correlations between functional imaging parameters. Results: The ratio of PET-derived SUVmean and diffusionweighted imaging-derived minimum ADC was introduced as a combined variable to predict tumor grade, outperforming single predictors. On the basis of a threshold ratio of 0.03, tumors could be classified as grade 2 with a sensitivity of 86% and a specificity of 100%. SUV and functional ADCs, as well as arterial contrast enhancement parameters, showed nonsignificant and mostly negligible correlations. Conclusion: Because receptor density and tumor cellularity appear to be independent, potentially complementary phenomena, the combined ratio of PET/MRI and SUVmean/ADCmin may be used as a novel biomarker allowing differentiation between grade 1 and grade 2 GEP NETs.
Involved external institutions
Germany (DE)How to cite
APA:
Adams, L.C., Bressem, K.K., Brangsch, J., Reimann, C., Nowak, K., Brenner, W., & Makowski, M.R. (2020). Quantitative 3d assessment of 68ga-dotatoc pet/mri with diffusion-weighted imaging to assess imaging markers for gastroenteropancreatic neuroendocrine tumors: Preliminary results. Journal of Nuclear Medicine, 61(7), 1021-1027. https://doi.org/10.2967/jnumed.119.234062
MLA:
Adams, Lisa C., et al. "Quantitative 3d assessment of 68ga-dotatoc pet/mri with diffusion-weighted imaging to assess imaging markers for gastroenteropancreatic neuroendocrine tumors: Preliminary results." Journal of Nuclear Medicine 61.7 (2020): 1021-1027.
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