Baseline and Exercise Predictors of V-O2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF

Karlsen T, Videm V, Halle M, Ellingsen O, Stoylen A, Dalen H, Delagardelle C, Larsen AI, Hole T, Mezzani A, Van Craenenbroeck EM, Beckers P, Pressler A, Christle JW, Winzer EB, Mangner N, Woitek FJ, Hoellriegel R, Snoer M, Feiereisen P, Valborgland T, Linke A, Prescott E (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Medicine and science in sports and exercise American College of Sports Medicine (ACSM)

Book Volume: 52

Pages Range: 810-819

Journal Issue: 4

DOI: 10.1249/MSS.0000000000002193

Abstract

Purpose This study aimed to investigate baseline, exercise testing, and exercise training-mediated predictors of change in peak oxygen uptake (V-O2peak) from baseline to 12-wk follow-up (ΔV-O2peak) in a post hoc analysis from the SMARTEX Heart Failure trial. Methods We studied 215 patients with heart failure with left ventricular ejection fraction (LVEF) ≤35%, and New York Heart Association (NYHA) classes II-III who were randomized to either supervised high-intensity interval training with exercise target intensity of 90%-95% of peak heart rate (HRpeak) or supervised moderate continuous training (MCT) with target intensity of 60%-70% of HRpeak, or who received a recommendation of regular exercise on their own. Predictors of ΔV-O2peak were assessed in two models: a logistic regression model comparing highest and lowest tertiles (baseline parameters) and a multivariate linear regression model (test/training/clinical parameters). Results The change in V-O2peak in response to the interventions (ΔV-O2peak) varied substantially, from-8.50 to +11.30 mL·kg-1·min-1. Baseline NYHA (class II gave higher odds vs III; odds ratio (OR), 7.1 (2.0-24.9); P = 0.002), LVEF (OR per percent, 1.1 (1.0-1.2); P = 0.005), and age (OR per 10 yr, 0.5 (0.3-0.8); P = 0.003) were associated with ΔV-O2peak. In the multivariate linear regression, 34% of the variability in ΔV-O2peak was explained by the increase in exercise training workload, ΔHRpeak between baseline and 12-wk posttesting, age, and ever having smoked. Conclusion Exercise training response (ΔV-O2peak) correlated negatively with age, LVEF, and NYHA class. The ability to increase workload during the training period and increased ΔHRpeak between baseline and the 12-wk test were associated with a positive outcome.

Involved external institutions

Nord University / Nord universitet NO Norway (NO) NTNU Trondheim - Norwegian University of Science and Technology NO Norway (NO) Technische Universität München (TUM) DE Germany (DE) St. Olavs University Hospital / St. Olavs Hospital Universitetssykehuset i Trondheim NO Norway (NO) Luxembourg Hospital Center / Centre Hospitalier de Luxembourg (CHL) LU Luxembourg (LU) Stavanger University Hospital NO Norway (NO) Antwerp University Hospital BE Belgium (BE) Technische Universität Dresden DE Germany (DE) Zealand University Hospital DK Denmark (DK) University of Copenhagen DK Denmark (DK)

How to cite

APA:

Karlsen, T., Videm, V., Halle, M., Ellingsen, O., Stoylen, A., Dalen, H.,... Prescott, E. (2020). Baseline and Exercise Predictors of V-O2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF. Medicine and science in sports and exercise , 52(4), 810-819. https://doi.org/10.1249/MSS.0000000000002193

MLA:

Karlsen, Trine, et al. "Baseline and Exercise Predictors of V-O2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF." Medicine and science in sports and exercise 52.4 (2020): 810-819.

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