A proof of principle experiment for microbeam radiation therapy at the Munich compact light source

Dombrowsky AC, Burger K, Porth AK, Stein M, Dierolf M, Guenther B, Achterhold K, Gleich B, Feuchtinger A, Bartzsch S, Beyreuther E, Combs SE, Pfeiffer F, Wilkens JJ, Schmid TE (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Radiation and Environmental Biophysics Springer Verlag (Germany)

Book Volume: 59

Pages Range: 111-120

Journal Issue: 1

DOI: 10.1007/s00411-019-00816-y

Abstract

Microbeam radiation therapy (MRT), a preclinical form of spatially fractionated radiotherapy, uses an array of microbeams of hard synchrotron X-ray radiation. Recently, compact synchrotron X-ray sources got more attention as they provide essential prerequisites for the translation of MRT into clinics while overcoming the limited access to synchrotron facilities. At the Munich compact light source (MuCLS), one of these novel compact X-ray facilities, a proof of principle experiment was conducted applying MRT to a xenograft tumor mouse model. First, subcutaneous tumors derived from the established squamous carcinoma cell line FaDu were irradiated at a conventional X-ray tube using broadbeam geometry to determine a suitable dose range for the tumor growth delay. For irradiations at the MuCLS, FaDu tumors were irradiated with broadbeam and microbeam irradiation at integral doses of either 3 Gy or 5 Gy and tumor growth delay was measured. Microbeams had a width of 50 µm and a center-to-center distance of 350 µm with peak doses of either 21 Gy or 35 Gy. A dose rate of up to 5 Gy/min was delivered to the tumor. Both doses and modalities delayed the tumor growth compared to a sham-irradiated tumor. The irradiated area and microbeam pattern were verified by staining of the DNA double-strand break marker γH2AX. This study demonstrates for the first time that MRT can be successfully performed in vivo at compact inverse Compton sources.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Helmholtz-Zentrum Dresden-Rossendorf (HZDR) DE Germany (DE)

How to cite

APA:

Dombrowsky, A.C., Burger, K., Porth, A.-K., Stein, M., Dierolf, M., Guenther, B.,... Schmid, T.E. (2020). A proof of principle experiment for microbeam radiation therapy at the Munich compact light source. Radiation and Environmental Biophysics, 59(1), 111-120. https://dx.doi.org/10.1007/s00411-019-00816-y

MLA:

Dombrowsky, Annique C., et al. "A proof of principle experiment for microbeam radiation therapy at the Munich compact light source." Radiation and Environmental Biophysics 59.1 (2020): 111-120.

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