Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography
Fasoula NA, Karlas A, Kallmayer M, Milik AB, Pelisek J, Eckstein HH, Klingenspor M, Ntziachristos V (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 47
Article Number: 101184
DOI: 10.1016/j.molmet.2021.101184
Abstract
Objective: Postprandial lipid profiling (PLP), a risk indicator of cardiometabolic disease, is based on frequent blood sampling over several hours after a meal, an approach that is invasive and inconvenient. Non-invasive PLP may offer an alternative for disseminated human monitoring. Herein, we investigate the use of clinical multispectral optoacoustic tomography (MSOT) for non-invasive, label-free PLP via direct lipid-sensing in human vasculature and soft tissues. Methods: Four (n = 4) subjects (3 females and 1 male, age: 28 ± 7 years) were enrolled in the current pilot study. We longitudinally measured the lipid signals in arteries, veins, skeletal muscles, and adipose tissues of all participants at 30-min intervals for 6 h after the oral consumption of a high-fat meal. Results: Optoacoustic lipid-signal analysis showed on average a 63.4% intra-arterial increase at ~ 4 h postprandially, an 83.9% intra-venous increase at ~ 3 h, a 120.8% intra-muscular increase at ~ 3 h, and a 32.8% subcutaneous fat increase at ~ 4 h. Conclusion: MSOT provides the potential to study lipid metabolism that could lead to novel diagnostics and prevention strategies by label-free, non-invasive detection of tissue biomarkers implicated in cardiometabolic diseases.
Involved external institutions
Germany (DE)How to cite
APA:
Fasoula, N.-A., Karlas, A., Kallmayer, M., Milik, A.B., Pelisek, J., Eckstein, H.-H.,... Ntziachristos, V. (2021). Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography. Molecular Metabolism, 47. https://doi.org/10.1016/j.molmet.2021.101184
MLA:
Fasoula, Nikolina-Alexia, et al. "Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography." Molecular Metabolism 47 (2021).
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