Polyscore of autonomic parameters for risk stratification of the elderly general population: The Polyscore study
Steger A, Dommasch M, Mueller A, Sinnecker D, Huster KM, Gotzler T, Gotzler O, Hapfelmeier A, Ulm K, Barthel P, Hnatkova K, Laugwitz KL, Malik M, Schmidt G (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 23
Pages Range: 789-796
Journal Issue: 5
Abstract
Aims: Present society is constantly ageing and elderly frequently suffer from conditions that are difficult and/or costly to treat if detected late. Effective screening of the elderly is therefore needed so that those requiring detailed clinical work-up are identified early. We present a prospective validation of a screening strategy based on a Polyscore of seven predominantly autonomic, non-invasive risk markers. Methods and results: Within a population-based survey in Germany (INVADE study), participants aged ≥60 years were enrolled between August 2013 and February 2015. Seven prospectively defined Polyscore components were obtained during 30-min continuous recordings of electrocardiogram, blood pressure, and respiration. Out of 1956 subjects, 168 were excluded due to atrial fibrillation, implanted pacemaker, or unsuitable recordings. All-cause mortality over a median 4-year follow-up was prospectively defined as the primary endpoint. The Polyscore divided the investigated population (n = 1788, median age: 72 years, females: 58%) into three predefined groups with low (n = 1405, 78.6%), intermediate (n = 326, 18.2%), and high risk (n = 57, 3.2%). During the follow-up, 82 (4.6%) participants died. Mortality in the Polyscore-defined risk groups was 3.4%, 7.4%, and 17.5%, respectively (P < 0.0001). The Polyscore-based mortality prediction was independent of Framingham score, diabetes, chronic kidney disease, and major stroke and/or myocardial infarction history. It was particularly effective in those aged <75 years (n = 1145). Conclusion: The Polyscore-based mortality risk assessment from short-term non-invasive recordings is effective in the elderly general population, especially those aged 60-74 years. Implementation of a comprehensive Polyscore screening of this age group is proposed to advance preventive medical care.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
Germany (DE)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
How to cite
APA:
Steger, A., Dommasch, M., Mueller, A., Sinnecker, D., Huster, K.M., Gotzler, T.,... Schmidt, G. (2021). Polyscore of autonomic parameters for risk stratification of the elderly general population: The Polyscore study. Europace, 23(5), 789-796. https://doi.org/10.1093/europace/euaa359
MLA:
Steger, Alexander, et al. "Polyscore of autonomic parameters for risk stratification of the elderly general population: The Polyscore study." Europace 23.5 (2021): 789-796.
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