Meal replacement by formula diet reduces weight more than a lifestyle intervention alone in patients with overweight or obesity and accompanied cardiovascular risk factors—the ACOORH trial

Halle M, Roehling M, Banzer W, Braumann KM, Kempf K, Mccarthy D, Schaller N, Predel HG, Scholze J, Fuhrer-Sakel D, Toplak H, Berg A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

European Journal of Clinical Nutrition Nature Publishing Group: Open Access Hybrid Model Option B

Book Volume: 75

Pages Range: 661-669

Journal Issue: 4

DOI: 10.1038/s41430-020-00783-4

Abstract

Background: As formula diets have demonstrated to be effective in reducing weight, we hypothesised that in patients with overweight or obesity and accompanied cardiovascular risk factors, combining a liquid formula diet with a lifestyle intervention is superior in reducing weight and improving cardiovascular risk factors than lifestyle intervention alone. Methods: In this multicenter RCT 463 participants with overweight or obesity (BMI: 27–35 kg/m²; at least one additional co-morbidity of the metabolic syndrome) were randomised (1:2) into either a control group with lifestyle intervention only (CON, n = 155) or a lifestyle intervention group including a liquid meal replacement (INT, n = 308). Both groups used telemonitoring devices (scales and pedometers), received information on healthy diet and were instructed to increase physical activity. Telemonitoring devices automatically transferred data into a personalised online portal and acquired data were discussed. INT obtained a liquid meal replacement substituting three meals/day (~1200 kcal) within the first week. During weeks 2–4, participants replaced two meals/day and during weeks 5–26 only one meal/day was substituted (1300–1500 kcal/day). Follow-up was conducted after 52 weeks. Intention-to-treat analyses were performed. Primary outcome was weight change. Secondary outcomes comprised changes in cardiometabolic risk factors including body composition and laboratory parameters. Results: From the starting cohort 360 (78%, INT: n = 244; CON: n = 116) and 317 (68%, INT: n = 216; CON: n = 101) participants completed the 26-weeks intervention phase and the 52-weeks follow-up. The estimated treatment difference (ETD) between both groups was −3.2 kg [−4.0; −2.5] (P < 0.001) after 12 weeks and −1.8 kg [−2.8; −0.8] (P < 0.001) after 52 weeks. Conclusions: A low-intensity lifestyle intervention combined with a liquid meal replacement is superior regarding weight reduction and improvement of cardiovascular risk factors than lifestyle intervention alone.

Involved external institutions

Verbund Katholischer Kliniken Düsseldorf gGmbH (VKKD) DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) Universität Hamburg (UHH) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Deutsche Sporthochschule Köln DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE) Albert-Ludwigs-Universität Freiburg DE Germany (DE) London Metropolitan University GB United Kingdom (GB)

How to cite

APA:

Halle, M., Roehling, M., Banzer, W., Braumann, K.M., Kempf, K., Mccarthy, D.,... Berg, A. (2021). Meal replacement by formula diet reduces weight more than a lifestyle intervention alone in patients with overweight or obesity and accompanied cardiovascular risk factors—the ACOORH trial. European Journal of Clinical Nutrition, 75(4), 661-669. https://dx.doi.org/10.1038/s41430-020-00783-4

MLA:

Halle, Martin, et al. "Meal replacement by formula diet reduces weight more than a lifestyle intervention alone in patients with overweight or obesity and accompanied cardiovascular risk factors—the ACOORH trial." European Journal of Clinical Nutrition 75.4 (2021): 661-669.

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